Macroamylasemia in patients with celiac disease

The American Journal of Gastroenterology
A RabsztynK Horvath

Abstract

Macroamylasemia is considered to be rarely associated with celiac disease (CD). We have evaluated patients in whom macroamylasemia or elevated total amylase (TA) led to the diagnosis of CD. These cases served as a catalyst for examining the prevalence of elevated TA and macroamylase (MA) in patients with active CD. Total amylase and MA measurements were performed in the sera of 124 celiac patients with positive antiendomysium and tissue transglutaminase tests, in 100 patients on gluten-free diet (GFD) with negative serology test results, and in the sera of 89 healthy controls. Macroamylasemia was measured by using the PEG precipitation method. Twenty-three newly diagnosed celiac patients had elevated serum amylase levels (>2 SD above the controls). The average TA and MA levels were significantly elevated in both celiac groups. The nonprecipitated amylase levels (pancreatic and salivary amylase fractions) were not different from those of the controls. Three controls (3.4%), 21 newly diagnosed celiac (16.8%), and seven patients on GFD (7%) had significantly elevated MA activity in their sera. A significant percentage of the newly diagnosed patients with CD have macroamylasemia. Serum MA remained elevated in some patients on stric...Continue Reading

References

Mar 1, 1988·American Journal of Surgery·A L Warshaw, M M Hawboldt
Jun 1, 1988·British Journal of Rheumatology·P HasselbacherF C Passero
Dec 1, 1988·Journal of Clinical Gastroenterology·S KatzB Napolitano
Jun 1, 1989·Digestive Diseases and Sciences·A Van Gossum, M Cremer
Jun 1, 1989·Gastroenterologia Japonica·H InoueT Yamamoto
Apr 1, 1989·Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine·S OkadaI Sakurabayashi
Nov 2, 1967·The New England Journal of Medicine·J E BerkR L Searcy
May 4, 1968·Lancet·M D LevittS R Cooperband
Sep 1, 1980·The American Journal of Medicine·H J HodgsonV S Chadwick
Feb 1, 1981·Digestive Diseases and Sciences·S K DuttaM D Levitt
Mar 1, 1995·British Journal of Rheumatology·M CutoloS Accardo
Jun 1, 1995·Journal of Clinical Gastroenterology·P RajvanshiS Gupta
Apr 1, 1993·Mayo Clinic Proceedings·P J GalassoJ F O'Brien
May 1, 1997·Annals of Clinical Biochemistry·Y Foo, P Konecny
May 1, 1997·Scandinavian Journal of Clinical and Laboratory Investigation·G BonettiR Moratti
Jul 2, 1998·Scandinavian Journal of Gastroenterology·T NotA Fasano

❮ Previous
Next ❯

Citations

Jan 1, 2008·Case Reports in Gastroenterology·Roman DepsamesYael Kopelman
Jan 21, 2016·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Marcela de Almeida MenezesCecília Queiroz Silva
May 11, 2002·The American Journal of Gastroenterology·David S Sanders
Apr 20, 2007·Digestive Diseases and Sciences·Zhanju LiuFuai Tang
Sep 14, 2006·Current Gastroenterology Reports·Lincoln Hernandez, Peter H Green
Dec 14, 2005·Current Opinion in Rheumatology·Susie K Lee, Peter Hr Green
Jul 16, 2013·Current Opinion in Gastroenterology·Matthew J DiMagno, Eugene P DiMagno
Jan 25, 2003·European Journal of Gastroenterology & Hepatology·D Sánchez-MuñozA Moro
Aug 19, 2020·Digestive Diseases and Sciences·Motasem AlkhayyatPrabhleen Chahal
Jun 12, 2003·World Journal of Gastroenterology : WJG·Giorgio La VillaGiacomo Laffi
Jan 9, 2009·Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)·A Torrent VernettaD Infante Pina
Mar 21, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Mario Plebani

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

The American Journal of Gastroenterology
Clare O'LearyFergus Shanahan
Scandinavian Journal of Clinical and Laboratory Investigation
G BonettiR Moratti
Digestive Diseases and Sciences
A Van Gossum, M Cremer
The American Journal of Medicine
H J HodgsonV S Chadwick
© 2021 Meta ULC. All rights reserved