Macroautophagy: a mechanism for mediating cell death or for promoting cell survival?

Kidney International
Wilfred Lieberthal

Abstract

Macroautophagy is a ubiquitous mechanism for the bulk removal of macromolecules and cell organelles from the cell. Periyasamy-Thandavan and colleagues report that cisplatin activates autophagy in renal tubular cells and that autophagy plays a role in decreasing apoptosis of tubular cells induced by cisplatin. This finding provides novel evidence that autophagy may play a role in ameliorating the effects of acute injury on the kidney.

References

Dec 2, 2000·Science·D J Klionsky, S D Emr
Sep 29, 2001·Archives of Histology and Cytology·Y Uchiyama
Nov 6, 2004·Science·Takahiro Shintani, Daniel J Klionsky
Nov 24, 2004·Nature Cell Biology·Shigeomi ShimizuYoshihide Tsujimoto
Dec 24, 2004·Journal of Cell Science·Daniel J Klionsky
Jun 2, 2005·Nature Reviews. Molecular Cell Biology·Julian J LumCraig B Thompson
Oct 4, 2005·The Journal of Clinical Investigation·Beth Levine, Junying Yuan
Aug 3, 2006·The Journal of Biological Chemistry·Anne Hamacher-BradyRoberta A Gottlieb
Mar 31, 2007·Nature Reviews. Drug Discovery·David C RubinszteinDaniel J Klionsky
Nov 28, 2007·Annual Review of Pathology·Mondira Kundu, Craig B Thompson
May 30, 2008·Kidney International·Sudharsan Periyasamy-ThandavanZheng Dong

❮ Previous
Next ❯

Citations

Jun 27, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H IzzedineJ C Soria
Aug 14, 2010·Journal of the American Society of Nephrology : JASN·Subhashini BolisettyAnupam Agarwal
Jan 10, 2014·Sleep & Breathing = Schlaf & Atmung·Lulu LiBaoyuan Chen
Aug 3, 2012·Kidney International·Man JiangZheng Dong
May 13, 2011·Kidney International·Andrea Havasi, Steven C Borkan
Apr 23, 2015·Experimental Biology and Medicine·Ya-Li ZhangShuo Yang
Nov 20, 2014·Journal of the American Society of Nephrology : JASN·Takahisa KawakamiJeremy S Duffield
Mar 16, 2012·American Journal of Physiology. Renal Physiology·Wilfred Lieberthal, Jerrold S Levine

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis