PMID: 11322545Apr 27, 2001Paper

Macrochelation, cyclometallation and G-quartet formation: N3- and C8-bound PdII complexes of adenine and guanine

Chemistry : a European Journal
C PriceAndrew Houlton

Abstract

The reactions of Pd(II) ions with a series of chelate-tethered derivatives of adenine and guanine have been studied and reveal a difference in the reactivity of the purine bases. Reactions of [PdCl2(MeCN)2] and A-alkyl-enH x Cl (alkyl = propyl or ethyl, A adenine, en = ethylenediamine) yield the monocationic species [PdCl(A-N3-Et-en)]+ (1) and [PdCl(A-N3-Pr-en)]+ (2). Both involve co-ordination at the minor groove site N3 of the nucleobase as confirmed by single-crystal X-ray analysis. Reactions with the analogous G-alkyl-enH x Cl derivatives (G=guanine, alkyl = ethyl or propyl) were more complex with a mixture of species being observed. For G-Et-en HCI a product was isolated which was identified as [PdCl(G-C8-Et-en)]+ (3). This compound contains a biomolecular metal-carbon bond involving C8 of the purine base. Crystallography of a product obtained from reaction of G-Pr-enH x Cl and [Pd(MeCN)4][NO3]2 reveals an octacationic tetrameric complex (4), in which each ligand acts to bridge two metal ions through a combination of a tridentate binding mode involving the diamine and N3 and monodentate coordination at N7.

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Citations

Jan 9, 2003·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Amol A Mungikar, Daniel Forciniti
Sep 7, 2011·Journal of the American Chemical Society·Shuai WangAn-Hui Lu
Jan 17, 2014·Chemical Society Reviews·Jingrun RanShi Zhang Qiao
Mar 5, 2014·Langmuir : the ACS Journal of Surfaces and Colloids·Manu SharmaAshok K Ganguli
Oct 29, 2004·Dalton Transactions : an International Journal of Inorganic Chemistry·Ludovic G BonnetStevan Simonovic
Jan 11, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Teresa F MastropietroGiovanni De Munno
Aug 10, 2006·Dalton Transactions : an International Journal of Inorganic Chemistry·Marta Morell CerdàBernhard Lippert
Jun 4, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Qin JiangZijian Guo
Jun 11, 2009·Dalton Transactions : an International Journal of Inorganic Chemistry·Bernhard Lippert, Deepali Gupta
Dec 20, 2002·Angewandte Chemie·Clayton PriceAndrew Houlton
Nov 16, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·N NagapradeepSandeep Verma
Nov 27, 2010·Chemical Communications : Chem Comm·N Nagapradeep, Sandeep Verma
Jul 23, 2011·Chemistry : a European Journal·Susana IbáñezBernhard Lippert
Oct 6, 2009·Inorganic Chemistry·Miguel A GalindoAndrew Houlton
Jun 19, 2009·Inorganic Chemistry·Jitendra Kumar, Sandeep Verma
Apr 23, 2015·Inorganic Chemistry·Indranil SinhaJens Müller
Jun 26, 2018·Chemical Reviews·Shigeki Kuwata, F Ekkehardt Hahn
Jul 20, 2004·Inorganic Chemistry·Juan P García-TeránLuis Lezama

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