PMID: 6989234Apr 1, 1980Paper

Macrocytosis and pure RBC anemia caused by azathioprine

American Journal of Diseases of Children
Y A DeClerckA J Pennisi

Abstract

Red blood cell macrocytosis is a wellknown complication of azathioprine therapy. In a group of 91 patients receiving azathioprine immunosuppressive therapy for renal graft, the mean corpuscular volume determined by an electronic cell counter was substantially higher than in the normal population. Selective erythroid hypoplasia is another known but much less frequent complication of azathioprine use. The case of a child who had a selective erythroid hypoplasia while receiving azathioprine immunosuppressive therapy for renal graft is reported. The patient recovered as the drug therapy was discontinued. With progressive reintroduction of the drug, a second decrease in the hemoglobin was seen when a dose of 2 mg/kg was reached although with a smaller dose, no recurrence of anemia was observed.

Citations

May 1, 1992·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·B Vogt, B A Fivush
Jan 1, 1993·Journal of Internal Medicine·G J CreemersC van der Heul
Mar 14, 2008·International Journal of Experimental Pathology·Gemma MolyneuxJohn A Turton
Dec 29, 2004·Transplantation Proceedings·A AgrawalT Augustine
Dec 18, 2014·Journal of Crohn's & Colitis·Axel U DignassEuropean Crohn’s and Colitis Organisation [ECCO]
Jul 1, 1988·Indian Journal of Pediatrics·D B Gradus, R N Fine
Feb 7, 2018·Current Treatment Options in Gastroenterology·Dhruvan PatelNabeel Khan

Related Concepts

Hypoplastic Anemia
Azathioprine Sulfate
Erythrocytosis
Transplantation, Homologous
Kidney Transplantation

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