PMID: 9428184Jan 15, 1998Paper

Macrofilaricidal effects of chloroquine on adult Onchocerca volvulus by local infiltration of palpable onchocercal nodules

Revista Da Sociedade Brasileira De Medicina Tropical
R H GuderianM E Chico

Abstract

The macrofilaricidal effects of local infiltration of high concentrations of chloroquine into the capsule of onchocercal nodules on adult worms of Onchocerca volvulus was determined. Six weeks post infiltration, histological examination of single nodules showed all adult worms to be dead. With nodule conglomerates, there was localized action of chloroquine only on the adult worms in the infiltrated nodule, with no diffusion of the drug to adjacent nodules. Chloroquine infiltration of young, recently formed nodules to reduce the adult worm load of infected individuals may be an alternative method to costly nodulectomy.

References

Oct 1, 1979·Annals of Tropical Medicine and Parasitology·J E McMahon
Sep 1, 1991·Transactions of the Royal Society of Tropical Medicine and Hygiene·R H GuderianP J Cooper
Oct 1, 1991·Annals of Tropical Medicine and Parasitology·B M MahmoudJ F Williams
Apr 5, 1986·Lancet·R H GuderianC D Mackenzie

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Citations

Mar 9, 2010·The American Journal of Tropical Medicine and Hygiene·Joseph KamgnoMichel Boussinesq

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