Macrolide-lincosamide-streptogramin B (MLS) resistance in cutaneous propionibacteria: definition of phenotypes

The Journal of Antimicrobial Chemotherapy
E A EadyW J Cunliffe

Abstract

Erythromycin-resistant propionibacteria isolated from the skin of antibiotic-treated acne patients were found to express four different patterns of resistance to a set of eight MLS antibiotics. The majority of isolates (48/89 strains) were constitutively resistant to 14- and 16-membered ring macrolide, lincosamide and streptogramin B-type antibiotics. MICs of josamycin (0.5-16 mg/l) and spiramycin (0.5-128 mg/l) were lower than those of erythromycin, oleandomycin and tylosin (64 to less than 512 mg/l). Two strains of Propionibacterium granulosum exhibited inducible MLS resistance. Both 14- and 16-membered ring macrolides and virginiamycin S induced clindamycin resistance in these strains. Fifteen isolates demonstrated a similar phenotype to the inducible strains but were non-inducible by erythromycin. A fourth group of strains demonstrated high level resistance to all five macrolides tested (MIC greater than or equal to 128 mg/l) but were sensitive to virginiamycin S. The phenotype displayed by these strains is not compatible with the expression of methylase genes as currently known, nor with the action of an erythromycin esterase which hydrolyses only 14-membered ring macrolides. The resistance patterns of 12 isolates could no...Continue Reading

Citations

Nov 23, 2011·European Journal of Clinical Pharmacology·P ZarogoulidisK Zarogoulidis
Oct 1, 1996·Diagnostic Microbiology and Infectious Disease·V D ShortridgeS K Tanaka
Apr 28, 2004·American Journal of Clinical Dermatology·Hiok-Hee Tan
Mar 26, 2003·The British Journal of Dermatology·J I RossJ H Cove
Apr 12, 2003·American Journal of Clinical Dermatology·Hiok-Hee Tan
Apr 14, 2021·International Journal of Dermatology·David M Weiner, William D James
Jan 26, 2002·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Yoshinori Nakajima
Jul 1, 1991·Antimicrobial Agents and Chemotherapy·R Leclercq, P Courvalin

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