Macrolide Resistance and Its Impacts on M. Pneumoniae Pneumonia in Children: Comparison of Two Recent Epidemics in Korea

Allergy, Asthma & Immunology Research
Jong Hyun KimJi Tae Choung

Abstract

The aim of this study was to investigate the change in macrolide resistance rate in pediatric Mycoplasma pneumoniae pneumonia and to evaluate the influence of macrolide-resistant M. pneumoniae (MRMP) on the clinical course of disease, by comparing 2 recent, consecutive epidemics in Korea. A total of 250 patients with M. pneumoniae pneumonia admitted to a single tertiary hospital were enrolled in this study. Detection of MRMP was based on specific point mutations in domain V of the 23S rRNA gene. The medical records of enrolled patients were reviewed retrospectively, and the clinical courses and laboratory data were compared. The macrolide resistance rate of M. pneumoniae was 51.1% (48/94) in the 2011 epidemic, and 87.2% (136/156) in the 2015 epidemic. All MRMP isolates had the A2063G point mutation. In comparison of 2 epidemics, the mean age of patients with M. pneumoniae pneumonia was increased, and the total febrile days and febrile days after initiation of macrolides were prolonged in the 2015 epidemic. Overall severity of MRMP or macrolide-susceptible M. pneumoniae (MSMP) pneumonia over 2 epidemics was not significantly changed. However, the proportion of patients who had a fever lasting more than 72 hours after initiation ...Continue Reading

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Citations

Nov 30, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jae Hong ChoiChanghwan Kim
Feb 14, 2020·BMC Infectious Diseases·Eun LeeUNKNOWN Pneumonia and Respiratory Disease Study Group of Korean Academy of Pediatric Allergy and Respiratory Disease
Aug 23, 2018·Korean journal of pediatrics·Ji Eun JeongJung Yeon Shim
Jun 23, 2020·Emerging Infectious Diseases·Yu-Chin ChenTu-Hsuan Chang

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Methods Mentioned

BETA
PCR

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SigmaPlot

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