Macrolide resistance based on the Erm-mediated rRNA methylation

Current Drug Targets. Infectious Disorders
G Maravić

Abstract

Macrolide, lincosamide and streptogramin B (MLSB) antibiotics are extensively used for the treatment of wide variety of clinically important Gram-positive bacteria. MLSB antibiotics inhibit protein biosynthesis by targeting the peptidyl transferase centre within the 50S ribosomal subunit. The most widespread mechanism of bacterial resistance to MLSB antibiotics, reported early after their introduction into clinical practice is the modification of the target site exhibited by a family of rRNA methyltransferases designated Erm. Using S-adenosyl-L-methionine, Erm enzymes catalyze mono- or dimethylation of a specific adenine residue in the 23S rRNA. The methyl group sterically hinders the MLSB binding site and disrupts the hydrogen bonding between the macrolides and the rRNA, thus rendering bacteria resistant. This review summarizes the current understanding of Erm-mediated resistance, in light of high-resolution structural data of bacterial ribosome and with specific focus on the results of recent genetic, biochemical and structural studies of Erm methyltransferases and their cognate rRNA substrate. Although many features of MLSB resistance remain indistinct, the present knowledge can now serve as the guidance for development of b...Continue Reading

Citations

Jan 5, 2006·Applied Microbiology and Biotechnology·S Jana, J K Deb
Jan 5, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Emel Sesli CetinMustafa Demirci
Apr 25, 2013·The Journal of Antibiotics·Stuart Shapiro
Mar 29, 2007·Nucleic Acids Research·Petr V SergievOlga A Dontsova
Apr 17, 2014·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Magdalena SzemrajEligia M Szewczyk
Jan 22, 2008·International Journal of Antimicrobial Agents·Emel Sesli CetinMustafa Demirci
Nov 2, 2005·Protein Science : a Publication of the Protein Society·Warren SunDinesh Christendat
Jul 14, 2010·FEMS Microbiology Letters·Ae Kyung ParkHyung Jong Jin
Sep 7, 2016·Antibiotics·Dubravko Jelić, Roberto Antolović
May 27, 2017·ACS Infectious Diseases·Roberta J Melander, Christian Melander
Sep 7, 2018·Open Biology·Anna Ovcharenko, Andrea Rentmeister
Jul 18, 2018·Polish Journal of Microbiology·Magdalena SzemrajEligia M Szewczyk
Jun 5, 2020·Trends in Molecular Medicine·Adam J Schaenzer, Gerard D Wright
Aug 12, 2021·Microbiology Spectrum·Loredana BaffoniDiana Di Gioia

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