PMID: 3215710Jan 1, 1988Paper

Macrolidic antibiotics: effects on primary in vitro antibody responses

International Journal of Immunopharmacology
M L VillaE Clerici

Abstract

The effect of two macrolidic antibiotics, josamycin and erythromycin, on the primary immune response in cultures of human peripheral blood mononuclear cells (PBMC), were studied using a soft agar hemolytic plaque assay. Both compounds induced an appreciable reduction in the primary antibody response in total PBMC cultures. The removal of plastic-adherent cells, however, profoundly modified the effect of macrolides on the immune response. Both josamycin and, to a lesser extent, erythromycin enhanced, rather than suppressed, the antibody response. Furthermore, the macrolide-induced immunodepression in cultures of total PBMC was completely reversed by the addition of catalase (8000 U/ml). Taken together, these findings suggest that the macrolide-induced depression of the antibody response depends upon the presence of adherent monocytic cells and is mediated by the production of hydrogen peroxide.

References

Jan 1, 1986·Chemotherapy·F FraschiniF Teodori
Jan 1, 1986·International Journal of Immunopharmacology·M L VillaE Clerici
Jan 1, 1985·Immunology Letters·M L VillaE Clerici
Jul 1, 1985·The Journal of Antimicrobial Chemotherapy·J J PocidaloS Kernbaum
Mar 1, 1981·The Journal of Infection·A W Segal
Jan 1, 1981·Journal of Immunological Methods·M L Villa, E Clerici
Jan 1, 1981·The Journal of Clinical Investigation·R K RootH L Malech

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Citations

Jul 1, 1996·Infection·B Van VlemS Ringoir
Oct 1, 1992·The Annals of Otology, Rhinology & Laryngology. Supplement·Y IinoA Yuo

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