Macromolecular agents with antimicrobial potentialities: A drive to combat antimicrobial resistance

International Journal of Biological Macromolecules
Muhammad BilalXuehong Zhang

Abstract

In recent years, the antimicrobial resistance (AMR) or multidrug resistance (MDR) has become a serious health concern and major challenging issue, worldwide. After decades of negligence, the AMR has now captured global attention. The increasing number of antibiotic-resistant strains has threatened the achievements of science and medicine since it inactivates conventional antimicrobial therapeutics. Scientists are trying to respond to AMR/MDR threat by exploring innovative platforms and new therapeutic strategies to tackle infections from these resistant strains and bypass treatment limitations related to these pathologies. The present review focuses on the utilization of bio-inspired novel constructs and their potential applications as novel antimicrobial agents. The first part of the review describes plant-based biological macromolecules containing an immense variety of secondary metabolites, which could be potentially used as alternative strategies to combat antimicrobial resistance. The second part discusses the potential of metal-based macromolecules as effective antimicrobial platforms for preventing infections from resistant strains. The third part comprehensively elucidates how nanoparticles, in particular, metal-integra...Continue Reading

References

Oct 12, 2012·International Journal of Nanomedicine·Supriya D MahajanStanley A Schwartz

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Citations

Sep 18, 2020·Expert Opinion on Drug Metabolism & Toxicology·Marzieh DanialiMohammad Abdollahi
Jun 15, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alla V LipeevaElvira E Shults
May 23, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jarosław WidelskiKrystyna Skalicka-Wozniak
Jul 12, 2019·AIMS Microbiology·Hector RudillaMiguel Viñas
Jan 10, 2020·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Ana Vitoria Araújo LimaPatrícia Maria Guedes Paiva
Jul 11, 2018·Frontiers in Chemistry·Patrícia M CarvalhoMarco M Domingues
Feb 23, 2019·International Journal of Environmental Research and Public Health·Muhammad BilalHafiz M N Iqbal
Sep 30, 2020·International Journal of Biological Macromolecules·Mehnaza ManzoorRafeeya Shams
Apr 13, 2019·International Journal of Biological Macromolecules·Mélanie L'EnfantCorinne Pau-Roblot

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Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.