Macromolecular mimicry in translation initiation: a model for the initiation factor IF2 on the ribosome

IUBMB Life
J M MorenoHans Uffe Sperling-Petersen

Abstract

Protein biosynthesis in bacteria is controlled by a number of translation factors. Recent data based on comparison of sequence and structure data of translation factors have established a novel hypothesis for their interaction with the ribosome: initiation, elongation, and termination factors may use a common or partly overlapping binding site on the ribosome in a process of macromolecular mimicry of an A-site-bound tRNA. This paper reviews structural knowledge and tRNA macromolecular mimicry involvement of translation initiation factor IF2. Furthermore, a model is proposed for the factor and its interaction with the ribosome during the formation of the translation initiation complex.

Citations

Feb 1, 2003·Journal of Molecular Biology·Brian Søgaard LaursenHans Uffe Sperling-Petersen
Mar 26, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Hans Peter SørensenKim Kusk Mortensen
Sep 3, 2011·Microbiology and Molecular Biology Reviews : MMBR·Natalie VerstraetenJan Michiels
Mar 10, 2005·Microbiology and Molecular Biology Reviews : MMBR·Brian Søgaard LaursenHans Uffe Sperling-Petersen
Jul 19, 2003·RNA·Stefano MarziJ Stephen Lodmell
Jun 7, 2005·Biochimica Et Biophysica Acta·Angela C Spencer, Linda L Spremulli
Sep 26, 2002·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Brian Søgaard LaursenHans Uffe Sperling-Petersen
Feb 26, 2003·The Journal of Biological Chemistry·Brian Søgaard LaursenDavid W Hoffman

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