PMID: 6160259Aug 1, 1980Paper

Macromolecular requirements for abrogation of Fv-1 restriction by murine leukemia viruses

Journal of Virology
R H BassinA Rein

Abstract

The molecular basis of abrogation of Fv-1 restriction in mouse cells by murine leukemia virus was investigated. Two different lines of experimentation indicated that high-molecular-weight viral RNA is required for abrogation. First, the decay of abrogating ability of virus stocks heated at 43 degrees C was quantitatively correlated with a loss of intact virion 35S RNA. Second, Act D virions, which lack such RNA although they contain normal structural proteins, failed to abrogate. These findings imply that abrogation does not result from the mere entry of virion structural proteins into a cell. Additional data indicate that the role of viral RNA in abrogation is not that of a template for DNA synthesis. Virus particles lacking reverse transcriptase activity as a result of either mutation or heat inactivation exhibit abrogating activity even though they do not synthesize detectable viral DNA. In addition, abrogation was shown to take place in the presence of cytosine arabinoside, an inhibitor of DNA synthesis. Thus, abrogation does not depend on viral or cellular DNA synthesis, and the role of viral RNA in this process must involve some other function. The nature of this viral function and its occurrence in Fv-1 permissive cells ...Continue Reading

References

Apr 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·J G Levin, M J Rosenak
Oct 1, 1975·Journal of Virology·G G LovingerM Hatanaka
Jul 1, 1976·Journal of Virology·S RasheedE Chan
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·P Jolicoeur, D Baltimore
Jul 15, 1976·Virology·J W Gautsch, H Meier
Sep 6, 1976·Biochimica Et Biophysica Acta·J M TaylorJ Summers
Jan 1, 1979·Current Topics in Microbiology and Immunology·P Jolicoeur
Nov 15, 1979·International Journal of Cancer. Journal International Du Cancer·B M BenjersG Duran-Troise
Aug 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·G M WahlG R Stark
Jul 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·M M Sveda, R Soeiro
May 1, 1973·International Journal of Cancer. Journal International Du Cancer·H Yoshikura
Jun 14, 1967·Journal of Molecular Biology·B Hirt
Oct 1, 1968·Journal of Cellular Physiology·S A Aaronson, G J Todaro
Sep 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·B I Gerwin, J B Milstien
Feb 19, 1971·Nature·R H BassinP J Fischinger
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·W K YangR H Bassin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.