Macromolecular substances as a dangerous factor in traditional Chinese medicine injections were determined by size-exclusive chromatography.

Toxicology Research
Yue LiWeigang Duan

Abstract

Macromolecular substances in traditional Chinese medicine injections (TCMIs) are expected to be a main dangerous factor causing anaphylactic or anaphylactoid reaction. The main aim of the study was to verify the macromolecular substances' anaphylactic or anaphylactoid reaction in guinea pigs and establish a size-exclusive chromatographic method to detect them. The macromolecular substances from six TCMIs (Danshen injection, Dengzhanxixin injection, Honghua injection, Qingkailing injection, Shuanghuanglian injection and Shuxuening injection) were prepared by removing substances with molecular weight less than 10 kDa with an ultra-filter. The anaphylactic and anaphylactoid reactions caused by original TCMIs, injections rich in or free of macromolecules were assayed in guinea pigs. The relationship between the amount of the macromolecular substances and peak area of chromatogram was established by size-exclusive chromatography. Injections free of macromolecules were not likely to cause anaphylactic and anaphylactoid reactions, but injections rich in macromolecular substances were more likely to do so. If the macromolecular substances with molecular weight bigger than 10 kDa were removed, the signal of macromolecular substances in ...Continue Reading

References

Dec 15, 2010·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Xiang-yu KongYan-ming Xie
Apr 20, 2012·Mini Reviews in Medicinal Chemistry·Qi-Mei Liu, Jian-Guo Jiang
Apr 7, 2015·Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan·Yuanyuan LiTing Guo
Jun 30, 2015·The American Journal of Chinese Medicine·Anqi WangYitao Wang
Jul 26, 2017·Journal of Chromatography. a·Hong WangZongtao Lin

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Citations

Feb 7, 2021·Journal of Chromatography. a·Weina MaLangchong He

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