PMID: 9165536May 1, 1997Paper

Macromolecules as novel transdermal transport enhancers for skin electroporation

Pharmaceutical Research
R VanbeverVéronique Préat

Abstract

Macromolecules were investigated as chemical enhancers of transdermal transport by skin electroporation. Although unable to enhance passive or iontophoretic transport, macromolecules are proposed to enhance electroporation-assisted delivery by stabilizing the increased permeability caused by high-voltage pulses. To test this hypothesis, we examined the timescale of transport, the influence of electrical protocol and the influence of macromolecule size, structure, and charge on enhancement of transdermal mannitol transport in vitro by heparin, dextran-sulfate, neutral dextran, and poly-lysine. Skin electroporation increased transdermal mannitol delivery by approximately two orders of magnitude. The addition of macromolecules further increased transport up to five-fold, in support of the proposed hypothesis. Macromolecules present during pulsing enhanced mannitol transport after pulsing for hours, apparently by a macromolecule-skin interaction. No enhancement was observed during passive diffusion or low-voltage iontophoresis, suggesting that macromolecules interact specifically with transport pathways created at high voltage. Although all macromolecules studied enhanced transport, those with greater charge and size were more effe...Continue Reading

Citations

Oct 22, 2002·Expert Opinion on Biological Therapy·Elka Touitou
Dec 20, 2005·Pharmaceutical Research·Stefania PaciniMarco Ruggiero
Sep 1, 2009·Journal of Clinical Pharmacology·José Juan Escobar-ChávezAlma Luisa Revilla-Vázquez
Mar 19, 2015·American Journal of Therapeutics·Ebtsam A MohammadAmr A Abd-Elghany
Aug 2, 2012·Toxicology and Industrial Health·Heidi P ChanHoward I Maibach
Aug 14, 2012·Medicinal Research Reviews·Josef Jampilek, Katerina Brychtova
Aug 24, 2017·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Yu A Nashchekina, M Raydan
Mar 26, 2004·Nature Reviews. Drug Discovery·Mark R PrausnitzRobert Langer
Jul 22, 2004·American Journal of Therapeutics·Victor M Meidan, Bozena B Michniak
Aug 14, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·B W Barry
Mar 4, 1999·International Journal of Pharmaceutics·A K BangaT K Ghosh
Jun 6, 2000·Advanced Drug Delivery Reviews·M R Prausnitz
Jun 17, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Nusrat A Motlekar, Bi-Botti C Youan

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