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Macromolecules from lobster axon membranes that bind cholinergic ligands and local anesthetics (recpetors-procaine-acetylcholine-nicotine-Na + and K + gates)

Proceedings of the National Academy of Sciences of the United States of America

Jan 1, 1972

Jeffrey L DenburgRonan O'Brien

PMID: 4500547

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Abstract

The technique of reversible equilibrium dialysis has been applied to the study of macromolecules that are essential for axonal conduction. A binding component from a preparation of an axon-plasma membrane has been characterized and shown to bind nicotine with a K(D) = 0.42 +/- 0.04 muM ...read more

Mentioned in this Paper

Potassium
Acetylcholine Sulfate (1: 1)
Dall Sheep
Parasympathomimetic Effect
Sodium
Tissue Membrane
Tritium
Structure-Activity Relationship
Procaina Serra
Erythrocytes
Paper Details
References
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    • References18
    • Citations21
  • Macromolecules from lobster axon membranes that bind cholinergic ligands and local anesthetics (recpetors-procaine-acetylcholine-nicotine-Na + and K + gates)

    Proceedings of the National Academy of Sciences of the United States of America

    Jan 1, 1972

    Jeffrey L DenburgRonan O'Brien

    PMID: 4500547

    DOI:

    Abstract

    The technique of reversible equilibrium dialysis has been applied to the study of macromolecules that are essential for axonal conduction. A binding component from a preparation of an axon-plasma membrane has been characterized and shown to bind nicotine with a K(D) = 0.42 +/- 0.04 muM ...read more

    Mentioned in this Paper

    Potassium
    Acetylcholine Sulfate (1: 1)
    Dall Sheep
    Parasympathomimetic Effect
    Sodium

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    Paper Details
    References
    • References18
    • Citations21
    • References18
    • Citations21
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