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Macromolecules from lobster axon membranes that bind cholinergic ligands and local anesthetics (recpetors-procaine-acetylcholine-nicotine-Na + and K + gates)

Proceedings of the National Academy of Sciences of the United States of America

Jan 1, 1972

J L DenburgR D O'Brien

PMID: 4500547

Abstract

The technique of reversible equilibrium dialysis has been applied to the study of macromolecules that are essential for axonal conduction. A binding component from a preparation of an axon-plasma membrane has been characterized and shown to bind nicotine with a K(D) = 0.42 +/- 0.04 muM ...read more

Mentioned in this Paper

Tissue Membrane
Structure-Activity Relationship
Toxin
Potassium
Dall Sheep
Cholinergic Receptors
Plasma Protein Binding Capacity
Nerve Conduction Function
Topical anesthetic
Tritium
Paper Details
References
  • References18
  • Citations26
12
  • References18
  • Citations26
123

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Axonal cholinergic binding macromolecule. Response to neuroactive drugs

Journal of Medicinal ChemistryJanuary 1, 1973
J L Denburg, R D O'Brien
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Macromolecules from lobster axon membranes that bind cholinergic ligands and local anesthetics (recpetors-procaine-acetylcholine-nicotine-Na + and K + gates)

Proceedings of the National Academy of Sciences of the United States of America

Jan 1, 1972

J L DenburgR D O'Brien

PMID: 4500547

DOI:

Abstract

The technique of reversible equilibrium dialysis has been applied to the study of macromolecules that are essential for axonal conduction. A binding component from a preparation of an axon-plasma membrane has been characterized and shown to bind nicotine with a K(D) = 0.42 +/- 0.04 muM ...read more

Mentioned in this Paper

Tissue Membrane
Structure-Activity Relationship
Toxin
Potassium
Dall Sheep
Cholinergic Receptors
Plasma Protein Binding Capacity
Nerve Conduction Function
Topical anesthetic
Tritium

Trending Feeds

Blastomycosis

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Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Related Papers

Journal of Medicinal Chemistry

Axonal cholinergic binding macromolecule. Response to neuroactive drugs

Journal of Medicinal ChemistryJanuary 1, 1973
J L Denburg, R D O'Brien
Paper Details
References
  • References18
  • Citations26
12
  • References18
  • Citations26
123
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