PMID: 11323081Apr 27, 2001Paper

Macronutrient-induced cascade of events leading to parallel changes in hypothalamic serotonin and insulin

Neuroscience and Biobehavioral Reviews
M Orosco, K Gerozissis

Abstract

Extracellular serotonin (5-HT) and insulin from hypothalamic PVN-VMH region follow parallel changes in response to specific macronutrient ingestion. Possible independent or causal mechanisms have been investigated. A common primary event might be pancreatic insulin secretion for both insulin entry into the brain and 5-HT synthesis through variations in the ratio of tryptophan over competitor amino acids. The steps of this cascade were found to account only partly for the changes in hypothalamic 5-HT and insulin. The central consequences of these metabolic effects may be modulated directly at the hypothalamic level. For instance, we observed a positive relation between the changes in insulin and 5-HT and the satiating potency of each nutrient. In addition, a direct action of dexfenfluramine on insulin has been found at the hypothalamic level showing that an activation of the serotonergic system immediately enhances insulin levels. This central event may be an important step in a cascade of events triggered by macronutrient ingestion leading to common hypothalamic insulin and 5-HT changes involved in feeding regulation.

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Citations

Jan 5, 2006·Cellular and Molecular Neurobiology·Claude RouchKyriaki Gerozissis
Sep 6, 2008·Cellular and Molecular Neurobiology·Sophie M BanasKyriaki Gerozissis
Feb 21, 2002·Behavioural Brain Research·Martine OroscoValérie Daugé
Oct 11, 2007·Diabetes, Obesity & Metabolism·David Russell-Jones, Rehman Khan
Apr 8, 2014·Comprehensive Psychiatry·Cristina Segura-GarcíaFrancesca Brambilla
Dec 4, 2012·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sherif AwadDileep N Lobo
Apr 15, 2008·European Journal of Pharmacology·Kyriaki Gerozissis
Apr 20, 2004·European Journal of Pharmacology·K Gerozissis
Jan 3, 2012·Molecular and Cellular Endocrinology·Ioannis PapazoglouKyriaki Gerozissis
Aug 5, 2014·The Journal of Nutritional Biochemistry·Marcos H OkudaLila M Oyama
Feb 10, 2016·Basic & Clinical Pharmacology & Toxicology·Caio C SestileElisabeth A Audi
Sep 17, 2002·The Proceedings of the Nutrition Society·Olle LjungqvistAnders Thorell
Feb 26, 2011·The British Journal of Nutrition·Christopher P HerreraJennie Brand-Miller
Feb 13, 2008·Psychophysiology·Laura K Zimmermann
Nov 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·D N D'SouzaL D Van de Kar
May 22, 2021·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Sarah SuhRana M Higgins

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