Macrophage activation by an ornithine-containing lipid or a serine-containing lipid.

Infection and Immunity
Y Kawai, K Akagawa

Abstract

alpha-N-(3-Acyloxyacyl)-ornithine (or -serine) is the structure of lipoamino acids obtained by us previously from some gram-negative bacteria (Y. Kawai and I. Yano, Eur. J. Biochem. 136:531-538, 1983; Y. Kawai, I. Yano, and K. Kaneda, Eur. J. Biochem. 171:73-80, 1988; Y. Kawai, I. Yano, K. Kaneda, and E. Yabuuchi, Eur. J. Biochem. 175:633-641, 1988). The 3-acyloxyacylamide structure is present in both the lipoamino acids and lipid A of lipopolysaccharide (endotoxin). The efficacy of lipoamino acids (an ornithine-containing lipid and a serine-containing lipid) in activating C3H/HeSlc mouse peritoneal exudate macrophages was compared with that of bacterial lipopolysaccharide, because the two types of substances were expected to exhibit similar biological activities and physiological functions on the basis of their structural similarities. Actually, the lipoamino acids, as well as lipopolysaccharide, strongly activated the macrophages to generate the immunoregulatory substances prostaglandin E2 and interleukin-1, but their effect on the induction of L929 cell cytolytic factor (a possible tumor necrosis factor), another immunoregulatory substance, was weaker than that of lipopolysaccharide. The effect of lipoamino acids on the cyto...Continue Reading

References

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Citations

Mar 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazunori GomiMasahiro Nishijima
Apr 12, 2014·Frontiers in Plant Science·Meriyem AktasFranz Narberhaus
Nov 23, 2007·Natural Product Reports·Markus Nett, Gabriele M König
Nov 7, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yannik K-H SchneiderJeanette Hammer Andersen
Aug 26, 2009·Progress in Lipid Research·Otto GeigerChristian Sohlenkamp
Oct 7, 2008·Journal of the American Society for Mass Spectrometry·Xi ZhangGavin E Reid

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