Macrophage activation syndrome associated with adult-onset Still's disease: a multicenter retrospective analysis.

Clinical Rheumatology
Ran WangQiong Fu

Abstract

To explore the clinical features, treatments, and prognostic factors of adult-onset Still's disease (AOSD)-associated macrophage activation syndrome (MAS), we conducted a multicenter retrospective clinical study of AOSD-associated MAS patients. AOSD patients were collected from six tertiary hospitals in China. Medical charts were reviewed and clinical information was recorded and analyzed. There were 447 AOSD patients enrolled into this retrospective clinical study. Among them, 55 were diagnosed with MAS. Liver dysfunction was the most reliable predictive factor for the screening of MAS in AOSD patients (OR = 75.744, 95%CI = 23.015-249.284, p < 0.0001). In multivariate analysis, clinical features including platelets < 100 × 109/L (OR = 9.546, p = 0.005), aspartate transaminase (AST) > 120 U/L (OR = 25.853, p < 0.0001), triglycerides > 3 mmol/L (OR = 12.9833, p = 0.011)), ferritin > 1500 ng/mL (OR = 5.513, p = 0.050), as well as hemophagocytosis in bone puncture (OR = 18.132, p = 0.001) were highly associated with the occurrence of MAS. The mortality rate of total AOSD patients was 4.47%, MAS was the main cause of death in AOSD patients (OR = 11.705, 95%CI = 4.783-28.647, p < 0.0001). PLT ≤ 100 × 109/L (p = 0.0001), fibrinogen <...Continue Reading

References

Oct 9, 2002·Journal of Pediatric Hematology/oncology·Lillian SungSheila S Weitzman
Aug 29, 2006·Pediatric Blood & Cancer·Jan-Inge HenterGritta Janka
Feb 6, 2009·Journal of Pediatric Hematology/oncology·Abha A GuptaSheila Weitzman
Dec 17, 2009·Hematology·Alexandra H Filipovich
Jun 22, 2012·Critical Care : the Official Journal of the Critical Care Forum·Demet DemirkolUNKNOWN Turkish Secondary HLH/MAS Critical Care Study Group
Oct 15, 2013·International Journal of Rheumatic Diseases·Rathindra N SarkarOmar S Mullick
Apr 24, 2014·Arthritis & Rheumatology·Shunichi Kumakura, Yohko Murakawa
Nov 12, 2014·Annual Review of Medicine·Grant S Schulert, Alexei A Grom
Sep 1, 2015·Arthritis & Rheumatology·Scott W Canna, Peter A Nigrovic
Sep 1, 2015·Arthritis & Rheumatology·Angelo RavelliUNKNOWN Paediatric Rheumatology International Trials Organisation the Childhood Arthritis and Rheumatology Research Alliance the Ped
Sep 3, 2016·Experimental and Therapeutic Medicine·Xiao-Tu XiBang-Han Ding
Oct 21, 2016·Saudi Medical Journal·Ahmad Z QureshiWaseem Amjad
Nov 16, 2016·Open Access Rheumatology : Research and Reviews·Mariam SiddiquiAnisha B Dua
Feb 6, 2017·Indian Journal of Clinical Biochemistry : IJCB·Neelima VermaManish Chugh
Feb 6, 2017·The American Journal of Case Reports·Mojgan Agha-AbbaslouArooj Hyat
Jul 21, 2017·Respiratory Medicine Case Reports·Aldo GuerrieriStefano Nava
Jul 13, 2019·Annals of the Rheumatic Diseases·Francesca MinoiaUNKNOWN Pediatric Rheumatology International Trials Organization, the Childhood Arthritis & Rheumatology Research Alliance, the Pedi

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Citations

Jul 14, 2020·Frontiers in Immunology·Serena ColafrancescoRoberta Priori
Dec 4, 2020·Oxford Medical Case Reports·Sabine Weber, Alexander L Gerbes
Jan 2, 2021·Seminars in Arthritis and Rheumatism·Shunli TangHong Fang

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