Macrophage adaptation in airway inflammatory resolution

European Respiratory Review : an Official Journal of the European Respiratory Society
Manminder KaurTracy Hussell

Abstract

Bacterial and viral infections (exacerbations) are particularly problematic in those with underlying respiratory disease, including post-viral infection, asthma, chronic obstructive pulmonary disease and pulmonary fibrosis. Patients experiencing exacerbations tend to be at the more severe end of the disease spectrum and are often difficult to treat. Most of the unmet medical need remains in this patient group. Airway macrophages are one of the first cell populations to encounter airborne pathogens and, in health, exist in a state of reduced responsiveness due to interactions with the respiratory epithelium and specific factors found in the airway lumen. Granulocyte-macrophage colony-stimulating factor, interleukin-10, transforming growth factor-β, surfactant proteins and signalling via the CD200 receptor, for example, all raise the threshold above which airway macrophages can be activated. We highlight that following severe respiratory inflammation, the airspace microenvironment does not automatically re-set to baseline and may leave airway macrophages more restrained than they were at the outset. This excessive restraint is mediated in part by the clearance of apoptotic cells and components of extracellular matrix. This implie...Continue Reading

References

Nov 27, 1999·FEMS Immunology and Medical Microbiology·J M HamentT F Wolfs
Apr 15, 2003·Journal of Cell Science·Caroline M Milner, Anthony J Day
Jun 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Koenraad F van der SluijsTom van der Poll
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew Evan WilliamsTracy Hussell
Dec 24, 2005·Critical Care Medicine·Delphine BorgelJean-Luc Diehl
Mar 18, 2006·American Journal of Respiratory Cell and Molecular Biology·Ulrich A MausJürgen Lohmeyer
Jul 5, 2006·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·P LehtinenO Ruuskanen
Jul 13, 2006·The Journal of Experimental Medicine·M Nusrat SharifLionel B Ivashkiv
Jul 19, 2006·Clinical Microbiology Reviews·Jonathan A McCullers
Oct 21, 2006·Journal of Leukocyte Biology·Andree SchmidtVeronika Grau
Jan 30, 2008·The Journal of Experimental Medicine·Arnaud DidierlaurentTracy Hussell
Apr 19, 2008·Nature Reviews. Immunology·Greg Lemke, Carla V Rothlin
Apr 19, 2008·European Journal of Immunology·Anja K MayerAlexander H Dalpke
Jul 16, 2008·Advances in Cancer Research·Rachel M A LingerDouglas K Graham
Jun 3, 2009·The Journal of Clinical Investigation·Arash ShahangianJane C Deng
Jan 28, 2010·Journal of Leukocyte Biology·Federica AlciatoGian Carlo Avanzi
May 7, 2010·The New England Journal of Medicine·Edgar BautistaKarl G Nicholson
Sep 9, 2010·The Journal of Infectious Diseases·Jonathan A McCullersBirgitta Henriques Normark
Oct 30, 2010·Current Opinion in Immunology·Carla V Rothlin, Greg Lemke
Apr 8, 2011·American Journal of Respiratory and Critical Care Medicine·William J JanssenPeter M Henson
Feb 5, 2013·Future Microbiology·Maryam HabibzayTracy Hussell
Mar 16, 2013·American Journal of Respiratory Cell and Molecular Biology·Rinat ZaynagetdinovTimothy S Blackwell
May 11, 2013·The Journal of Infectious Diseases·Ann R FalseyEdward E Walsh
May 16, 2013·American Journal of Respiratory Cell and Molecular Biology·Alexander V MisharinHarris Perlman
Jun 28, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hazem E GhoneimJonathan A McCullers
Jul 10, 2013·Intensive Care Medicine·Caroline GuignantGuillaume Monneret
Jan 22, 2014·Nature Reviews. Immunology·Tracy Hussell, Thomas J Bell
Mar 5, 2014·Nature Reviews. Microbiology·Jonathan A McCullers
Jan 22, 2015·Mucosal Immunology·Toshifumi FujimoriTracy Hussell

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Citations

Feb 7, 2016·Asian Pacific Journal of Tropical Medicine·Ji-Hui YuJie-Ru You
Apr 28, 2016·Seminars in Immunopathology·C T RobbA G Rossi
Jul 28, 2016·Cell Host & Microbe·Tamas DolowschiakWolf-Dietrich Hardt
Feb 12, 2017·Pflügers Archiv : European journal of physiology·Siamon Gordon, Luisa Martinez-Pomares
May 12, 2021·Molecules and Cells·Yeon Duk WooDoo Hyun Chung
Jun 10, 2021·European Journal of Immunology·Stephen J Jenkins, Judith E Allen

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