Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β

Journal of Hepatology
Ghulam IlyasMark J Czaja

Abstract

Overactivation of the innate immune response underlies many forms of liver injury including that caused by hepatotoxins. Recent studies have demonstrated that macrophage autophagy regulates innate immunity and resultant tissue inflammation. Although hepatocyte autophagy has been shown to modulate hepatic injury, little is known about the role of autophagy in hepatic macrophages during the inflammatory response to acute toxic liver injury. Our aim therefore was to determine whether macrophage autophagy functions to down regulate hepatic inflammation. Mice with a LysM-CRE-mediated macrophage knockout of the autophagy gene ATG5 were examined for their response to toxin-induced liver injury from D-galactosamine/lipopolysaccharide (GalN/LPS). Knockout mice had increased liver injury from GalN/LPS as determined by significant increases in serum alanine aminotransferase, histological evidence of liver injury, positive terminal deoxynucleotide transferase-mediated deoxyuridine triphosphate nick end-labeling, caspase activation and mortality as compared to littermate controls. Levels of proinflammatory tumor necrosis factor and interleukin (IL)-6 hepatic mRNA and serum protein were unchanged, but serum IL-1β was significantly increased ...Continue Reading

References

May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M J CzajaP Schmiedeberg
Mar 9, 1999·FEBS Letters·W van MolleC Libert
Jul 28, 2001·European Journal of Gastroenterology & Hepatology·G Ramadori, T Armbrust
Nov 16, 2006·Liver International : Official Journal of the International Association for the Study of the Liver·Manfred BilzerAlexander L Gerbes
Jul 31, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jacquelyn J MaherJames C Ryan
Jan 24, 2009·The Journal of Clinical Investigation·Avlin B ImaedaWajahat Z Mehal
Mar 24, 2009·Annual Review of Immunology·Charles A Dinarello
Jan 15, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·David H AdamsHartmut Jaeschke
Jul 28, 2010·Gastroenterology·Wen-Xing DingXiao-Ming Yin
Oct 5, 2010·Annual Review of Pharmacology and Toxicology·Debra L LaskinJeffrey D Laskin
Oct 28, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yongjun WangMark J Czaja
Sep 21, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hong-Min NiWen-Xing Ding
Sep 5, 2012·The Journal of Clinical Investigation·Jan PetrasekGyongyi Szabo
Sep 18, 2012·Gastroenterology·Paul Kubes, Wajahat Z Mehal
Oct 25, 2012·Digestive Diseases·Gyongyi SzaboShashi Bala
Jun 19, 2013·Autophagy·Mark J CzajaXiao-Ming Yin
Sep 26, 2013·Nature Reviews. Immunology·Vojo DereticShizuo Akira

❮ Previous
Next ❯

Citations

Jan 5, 2016·Digestive Diseases and Sciences·Mark J Czaja
Oct 13, 2015·Journal of Hepatology·Wen-Xing Ding, Hartmut Jaeschke
May 1, 2016·Alcoholism, Clinical and Experimental Research·Shaogui WangWen-Xing Ding
Feb 25, 2017·Advanced Healthcare Materials·Shasha ZhuLongping Wen
May 5, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Enpeng ZhaoMark J Czaja
Mar 23, 2018·Journal of Cellular and Molecular Medicine·Jifeng ZhuChuan Su
Nov 15, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kojiro NakamuraJerzy W Kupiec-Weglinski
Jul 30, 2016·American Journal of Physiology. Gastrointestinal and Liver Physiology·Gadi LalazarMark J Czaja
Aug 14, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Xiaojing WangGyongyi Szabo
Apr 8, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·So-Young RahUh-Hyun Kim
Feb 29, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yang ShenMark J Czaja
Mar 10, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Heather FrancisFanyin Meng
May 27, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claudia ZannettiUzma Hasan
Apr 10, 2019·Alcoholism, Clinical and Experimental Research·Ghulam IlyasMark J Czaja
Sep 29, 2019·Toxicology and Industrial Health·Raven E UliemeWorlanyo E Gato
Oct 17, 2019·International Journal of Molecular Sciences·Shengmin YanXiao-Ming Yin
Dec 5, 2019·Frontiers in Immunology·Andrea Kristina HorstLinda Diehl
Oct 12, 2019·World Journal of Hepatology·Laura Bainy Rodrigues de FreitasMário Reis Álvares-da-Silva
Mar 7, 2019·Immune Network·Jinju Lee, Hun Sik Kim
Sep 13, 2018·International Journal of Molecular Sciences·Lili JinDianbao Zhang
Apr 23, 2019·Experimental and Therapeutic Medicine·Xiaotian DongHongcui Cao
Aug 1, 2020·Frontiers in Immunology·Jacob D PainterOmid Akbari
Jun 13, 2020·Archives of Toxicology·Qiuhua TanZhengquan Su
Oct 7, 2020·Children·Fu-Chen HuangSung-Chou Li
Oct 30, 2020·Frontiers in Pharmacology·Ping GengXunlong Shi
Dec 6, 2020·International Journal of Biological Macromolecules·Fa-Quan ZhaoQiang-Song Wang
Jan 15, 2021·Cellular and Molecular Gastroenterology and Hepatology·Jiro KusakabeShinji Uemoto
Dec 29, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jian ZouJian-Bo Wan
Feb 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dorit AvniSarah Spiegel
Dec 19, 2019·Journal of Hepatology·Younis HazariGuido Kroemer
Feb 16, 2021·World Journal of Hepatology·Elias KouroumalisDimitrios N Samonakis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

ATG proteins

The discovery of autophagy-related ('ATG') proteins in the 1990s greatly advanced the mechanistic understanding of autophagy and clarified the fact that autophagy serves important roles in various biological processes.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Related Papers

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Luis FontanaMark J Czaja
American Journal of Physiology. Gastrointestinal and Liver Physiology
Michele T PritchardLaura E Nagy
Apoptosis : an International Journal on Programmed Cell Death
Ji-Hyun ParkKwan-Kyu Park
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Dan TakeuchiMasaru Miyazaki
© 2021 Meta ULC. All rights reserved