Macrophage Bactericidal Activities against Staphylococcus aureus Are Enhanced In Vivo by Selenium Supplementation in a Dose-Dependent Manner

PloS One
Mourad AribiJean-Luc Aymeric

Abstract

Dietary selenium is of fundamental importance to maintain optimal immune function and enhance immunity during infection. To this end, we examined the effect of selenium on macrophage bactericidal activities against Staphylococcus aureus. Assays were performed in golden Syrian hamsters and peritoneal macrophages cultured with S. aureus and different concentrations of selenium. Infected and selenium-supplemented animals have significantly decreased levels of serum nitric oxide (NO) production when compared with infected but non-selenium-supplemented animals at day 7 post-infection (p < 0.05). A low dose of 5 ng/mL selenium induced a significant decrease in macrophage NO production, but significant increase in hydrogen peroxide (H2O2) levels (respectively, p = 0.009, p < 0.001). The NO production and H2O2 levels were significantly increased with increasing concentrations of selenium; the optimal macrophage activity levels were reached at 20 ng/mL. The concentration of 5 ng/mL of selenium induced a significant decrease in the bacterial arginase activity but a significant increase in the macrophage arginase activity. The dose of 20 ng/mL selenium induced a significant decrease of bacterial growth (p < 0.0001) and a significant incre...Continue Reading

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Citations

Dec 15, 2015·International Immunopharmacology·Wafa NouariMourad Aribi
Nov 14, 2018·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Maroua MilianiMourad Aribi
Sep 7, 2019·Biological Trace Element Research·Sarah E SumnerGirish S Kirimanjeswara
Sep 12, 2018·Nutrients·Joseph C Avery, Peter R Hoffmann
Apr 25, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Tímea MosolygóGabriella Spengler
Apr 24, 2019·Journal of Immunology Research·Shuai WangShiyan Qiao
May 20, 2020·Frontiers in Oncology·Marina SerraAlessio Menga

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Methods Mentioned

BETA
lavage
ELISA

Software Mentioned

SPSS
ImageJ

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