Macrophage-Based Approaches for Cancer Immunotherapy.

Cancer Research
Nicholas R AndersonMichael Klichinsky

Abstract

Adoptive cell therapy with genetically modified T cells has generated exciting outcomes in hematologic malignancies, but its application to solid tumors has proven challenging. This gap has spurred the investigation of alternative immune cells as therapeutics. Macrophages are potent immune effector cells whose functional plasticity leads to antitumor as well as protumor function in different settings, and this plasticity has led to notable efforts to deplete or repolarize tumor-associated macrophages. Alternatively, macrophages could be adoptively transferred after ex vivo genetic modification. In this review, we highlight the role of macrophages in solid tumors, the progress made with macrophage-focused immunotherapeutic modalities, and the emergence of chimeric antigen receptor macrophage cell therapy.

References

Nov 1, 1988·European Journal of Cancer & Clinical Oncology·S DumontJ Bartholeyns
Mar 31, 2000·Nature Medicine·R A ClynesJ V Ravetch
Mar 4, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Lawrence S Lamb, Richard D Lopez
May 31, 2006·Cancer Immunology, Immunotherapy : CII·D RitchieH M Prince
Oct 25, 2007·Nature Reviews. Cancer·Mario P Colombo, Silvia Piconese
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Apr 14, 2009·Biochimica Et Biophysica Acta·Michele De Palma, Luigi Naldini
May 5, 2009·The Journal of Clinical Investigation·Liping SongLeonid S Metelitsa
Apr 19, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Steven A RosenbergMark E Dudley
May 26, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Edmund K MoonSteven M Albelda
Jul 9, 2011·Nature Immunology·E John Wherry
Jul 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher SchlieheMarcus Groettrup
Sep 14, 2011·The Journal of Clinical Investigation·Tangying LuDmitry Gabrilovich
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Stephen B WillinghamIrving L Weissman
Mar 28, 2012·Proceedings of the National Academy of Sciences of the United States of America·Badreddin EdrisMatt van de Rijn
Jul 7, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sylvia AdamsSandra Demaria
Sep 5, 2012·The Journal of Experimental Medicine·Alexandre P A TheocharidesJean C Y Wang
Jun 1, 2013·Science·Kipp WeiskopfK Christopher Garcia
Jul 3, 2013·Methods : a Companion to Methods in Enzymology·Rens BrasterMarjolein van Egmond
Sep 24, 2013·Nature Medicine·Stephanie M PyonteckJohanna A Joyce
Jan 17, 2014·The Journal of Clinical Investigation·Nuray GülMarjolein van Egmond
Mar 29, 2014·F1000prime Reports·Fernando O Martinez, Siamon Gordon
Apr 30, 2014·Cancer Immunology Research·Yonit Lavin, Miriam Merad
Jun 4, 2014·Cold Spring Harbor Perspectives in Biology·E Richard Stanley, Violeta Chitu
Jun 13, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Edmund K MoonSteven M Albelda
Nov 5, 2014·Frontiers in Immunology·Paola Italiani, Diana Boraschi

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Citations

Jun 4, 2021·Immunotherapy·Lidia GattoAlba Ariela Brandes
Jun 3, 2021·International Journal of Molecular Sciences·Sarah Cunningham, Holger Hackstein
Jul 3, 2021·International Journal of Molecular Sciences·Huogang WangDavid W Chan
Jun 15, 2021·Journal of Immunology Research·Saghar PahlavanneshanMohsen Basiri
Jul 30, 2021·Frontiers in Immunology·Daniel BodeDavid G Kent
Oct 10, 2021·Biomarker Research·Yingqi QiuYuhua Li

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