Macrophage cell therapy in renal disease.

Seminars in Nephrology
David Ferenbach, David Kluth

Abstract

Macrophages play an important role in many aspects of tissue injury, inflammation, and repair. Macrophage accumulation is found in most forms of renal disease and depletion studies have shown that they contribute to injury. However, it is also clear that monocytes and macrophages can develop reparative properties that are critical to disease resolution. A number of studies have now shown that macrophages can be transduced or stimulated ex vivo, injected after the initiation of disease, and localize preferentially to the site of renal inflammation. Such macrophage cell therapy can result in reduced inflammation and fibrosis and lead to improved renal function and attenuation of proteinuria. These studies provide a platform for future translational approaches in human renal disease.

References

Apr 1, 1997·Kidney International·M Kitamura, T S Sütö
May 16, 2000·Journal of Leukocyte Biology·C WeberH W Ziegler-Heitbrock
Oct 29, 2000·Journal of the American Society of Nephrology : JASN·Maria Pia RastaldiGiuseppe D'Amico
Dec 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·H YamagishiY Utsunomiya
Mar 20, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D C KluthA J Rees
Apr 6, 2002·Science·Priit TederPaul W Noble
Dec 19, 2002·The Journal of Clinical Investigation·Masashi NishidaIekuni Ichikawa
Dec 25, 2002·Molecular Therapy : the Journal of the American Society of Gene Therapy·Heather M WilsonDavid C Kluth
Mar 22, 2003·Blood·Frank A D T G WagenerCarl G Figdor
Mar 28, 2003·Journal of the American Society of Nephrology : JASN·Yohei IkezumiDavid J Nikolic-Paterson
Apr 23, 2003·Journal of the American Society of Nephrology : JASN·Guoqiang ZhangAllison A Eddy
Nov 25, 2004·American Journal of Physiology. Renal Physiology·Yuan-Ji DayMark D Okusa
Dec 3, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fiona Y ChowGregory H Tesch
Dec 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sarah L PullThaddeus S Stappenbeck
Jan 5, 2005·The Journal of Clinical Investigation·Jeremy S DuffieldJohn P Iredale
Mar 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yukai HeLouis D Falo
May 18, 2005·Biochemical and Biophysical Research Communications·Masashi NishidaKenji Hamaoka
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Robert D StoutJill Suttles
Aug 30, 2005·The American Journal of Pathology·Claire Lewis, Craig Murdoch
Oct 28, 2005·The American Journal of Pathology·Jeremy S DuffieldJeremy Hughes
Dec 3, 2005·Nature Reviews. Immunology·Siamon Gordon, Philip R Taylor
Jan 18, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sang-Kyung JoHyoung-Kyu Kim
Mar 30, 2007·The American Journal of Pathology·Volha NinichukHans-Joachim Anders
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jonathan A FallowfieldJohn P Iredale
May 9, 2007·The Journal of Experimental Medicine·Ludovic ArnoldBénédicte Chazaud
Nov 7, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Gang Jee KoHyoung Kyu Kim
Nov 21, 2007·The Journal of Experimental Medicine·Matthias NahrendorfMikael J Pittet
Feb 1, 2008·Journal of the American Society of Nephrology : JASN·Juliane ScholzChristian Kurts
May 10, 2008·The American Journal of Pathology·Ying WangDavid C H Harris
Jun 19, 2008·Kidney International·D Ferenbach, J Hughes
Sep 20, 2008·Nephron. Experimental Nephrology·Gilbert R KinseyMark D Okusa
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Dec 25, 2008·Annual Review of Immunology·Fernando O MartinezSiamon Gordon
Mar 24, 2009·Annual Review of Immunology·Andrea M Cooper

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Citations

May 28, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Lei ZhangLi-Rong Hao
Jul 14, 2010·Seminars in Nephrology·Steven J ChadbanJeremy Hughes
Jul 14, 2010·Seminars in Nephrology·Madeleine A VernonJeremy Hughes
Oct 5, 2013·Transplantation·George H Tse, Jeremy Hughes
Jul 1, 2014·Optics Letters·Stratis TzoumasVasilis Ntziachristos

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