PMID: 9184260May 1, 1997Paper

Macrophage-colony stimulating factor (M-CSF) is increased in the synovial-like membrane of the periprosthetic tissues in the aseptic loosening of total hip replacement (THR)

Clinical Rheumatology
J W XuS Santavirta

Abstract

The aim of the study was to assess the eventual presence, cellular localization and extent of expression of the osteoclast activating cytokine M-CSF (CSF-1) in the periprosthetic tissues around loose total hip replacement (THR). Synovial-like membrane was obtained from the implant-to-bone interface and pseudocapsule from ten total hip revisions performed for aseptic loosening and compared to ten hip synovial tissue samples obtained from ten patients who had primary THR for osteoarthritis. Avidin-biotinperoxidase complex (ABC) and alkaline phosphatase-anti-alkaline phosphatase (APAAP) methods were used for staining and VIDAS image analysis for quantification. M-CSF was mainly produced by macrophages, which often contained wear particles, but also by some fibroblasts and vascular endothelial cells. The number of cells containing (per one mm2 tissue) clearly increased in the interface (1585 +/- 212; p < 0.01) and pseudocapsular (1456 +/- 248; p < 0.01) tissue compared to synovial tissue (543 +/- 118). The present findings suggest, that inflammatory foreign-body type of response enhances expression of M-CSF in cases of aseptic loosening of THR. M-CSF produced in the synovial-like membrane in the implant-bone interface may contribut...Continue Reading

References

Sep 1, 1991·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·N TakahashiT Suda
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Jan 1, 1983·Journal of Cellular Biochemistry·E R StanleyS H Bartelmez
Jan 1, 1996·Scandinavian Journal of Rheumatology·V WarisY T Konttinen

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Citations

Apr 28, 2004·Biomaterials·D R HaynesH Zreiqat
Oct 18, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Weiping RenPaul H Wooley
Jun 29, 2013·The Journal of Arthroplasty·Peter N ChalmersBrett R Levine
May 22, 2009·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Derek C LaceyJohn A Hamilton
Mar 17, 2006·Biomaterials·J P SpanogleS B Goodman
Mar 16, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jami MandelinYrjö T Konttinen
Jan 16, 2004·Gene Therapy·P H Wooley, E M Schwarz
Mar 26, 2008·Journal of Dental Research·H KitauraN Yoshida
Mar 3, 2010·American Journal of Respiratory and Critical Care Medicine·Silvia NausHermann J Ziltener
May 12, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A SabokbarN A Athanasou
Dec 2, 2011·Clinical Orthopaedics and Related Research·Vinod DasaWilliam M Mihalko
Aug 12, 2008·The Journal of the American Academy of Orthopaedic Surgeons·Rocky S TuanUNKNOWN Implant Wear Symposium 2007 Biologic Work Group
Apr 27, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Eliza S HartmannSusanne Mayer-Wagner

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