Macrophage-Derived Exosomal Mir-155 Regulating Cardiomyocyte Pyroptosis and Hypertrophy in Uremic Cardiomyopathy

JACC. Basic to Translational Science
Bin WangBi-Cheng Liu

Abstract

miR-155 was synthesized and loaded into exosomes in increased infiltration of macrophages in a uremic heart. The released exosomal fusion with the plasma membrane leads to the release of miR-155 into the cytosol and translational repression of forkhead transcription factors of the O class (FoxO3a) in cardiomyocytes. Finally, macrophage-derived miR-155-containing exosomes promoted cardiomyocyte pyroptosis and uremic cardiomyopathy changes (cardiac hypertrophy and fibrosis) by directly targeting FoxO3a in uremic mice.

Citations

Jan 5, 2021·Frontiers in Cardiovascular Medicine·Ruicong XueChen Liu
Jan 30, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Binh Yen NguyenXin Wang
Apr 2, 2021·International Journal of Cardiology·Ampadu O JacksonShiyin Long
Aug 3, 2021·Frontiers in Medicine·Cheng ChenChangying Xing
Aug 10, 2021·Frontiers in Molecular Biosciences·Xiaoxiao ShanYing Xie
Aug 31, 2021·Molecular Therapy. Nucleic Acids·Jinning GaoKai Shao

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Methods Mentioned

BETA
electrophoresis
PCR
fluorescence microscopy
transmission electron microscopy
flow cytometry

Software Mentioned

Prism
FlowJo
GraphPad

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