PMID: 8604013Mar 1, 1996Paper

Macrophage dysfunction following the phagocytosis of IgG-coated erythrocytes: production of lipid peroxidation products

Journal of Leukocyte Biology
D J LoegeringJ W Eaton

Abstract

The phagocytosis of erythrocytes may contribute to the increased susceptibility to life-threatening infections in patients with burn injury, sickle cell anemia, and malaria. The phagocytosis of immunoglobulin G-coated erythrocytes (EIgG) is followed by a transient depression of several macrophage functions including phagocytosis, respiratory burst capacity, and killing of bacteria. The present study suggests the possibility that after erythrophagocytosis hemoglobin-derived iron conspires with reactive oxygen products of the macrophage respiratory burst to cause oxidant damage to the phagocyte. Challenge of elicited peritoneal macrophages with EIgG phagocytosis was followed by an increase in lipid peroxidation as assessed by thiobarbituric acid-reactive substances (TBARS). Doses of EIgG associated with increased TBARS also caused a depression of Fc receptor-mediated phagocytosis and phorbol myristate acetate (PMA)-stimulated hydrogen peroxide production. Time course experiments demonstrated that the increase in TBARS coincided with the depression of macrophage function. There was no increase in TBARS following the phagocytosis of IgG-coated erythrocyte ghosts, suggesting that hemoglobin iron is involved in the generation of TBAR...Continue Reading

Citations

Dec 22, 1999·The American Journal of Physiology·H TsukamotoG Brittenham
Aug 16, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hongyun SheHidekazu Tsukamoto
Mar 15, 2003·The Journal of Biological Chemistry·Shigang XiongHidekazu Tsukamoto
Jun 16, 2004·Clinical and Experimental Immunology·L HarhajiV Trajkovic
Mar 15, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M L ReficiD J Loegering
Feb 24, 2000·The Journal of Pathology·M M Kockx, M W Knaapen
Mar 5, 2003·Arteriosclerosis, Thrombosis, and Vascular Biology·Mark M KockxHidde Bult
Nov 12, 2010·Journal of the Royal Society, Interface·Charles F BellowsJoseph D Brain
Apr 25, 2000·Biochemical and Biophysical Research Communications·C A RichardD J Loegering
Jan 21, 2000·Free Radical Biology & Medicine·M J Raley, D J Loegering
Nov 13, 2009·International Journal of Cardiology·Dimitrios N TziakasHarisios Boudoulas

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