Macrophage Dysregulation and Impaired Skin Wound Healing in Diabetes.

Frontiers in Cell and Developmental Biology
Pijus K Barman, Timothy J Koh

Abstract

Monocytes (Mo) and macrophages (Mϕ) play important roles in normal skin wound healing, and dysregulation of wound Mo/Mϕ leads to impaired wound healing in diabetes. Although skin wound Mϕ originate both from tissue resident Mϕ and infiltrating bone marrow-derived Mo, the latter play dominant roles during the inflammatory phase of wound repair. Increased production of bone marrow Mo caused by alterations of hematopoietic stem and progenitor cell (HSPC) niche and epigenetic modifications of HSPCs likely contributes to the enhanced number of wound Mϕ in diabetes. In addition, an impaired transition of diabetic wound Mϕ from "pro-inflammatory" to "pro-healing" phenotypes driven by the local wound environment as well as intrinsic changes in bone marrow Mo is also thought to be partly responsible for impaired diabetic wound healing. The current brief review describes the origin, heterogeneity and function of wound Mϕ during normal skin wound healing followed by discussion of how dysregulated wound Mϕ numbers and phenotype are associated with impaired diabetic wound healing. The review also highlights the possible links between altered bone marrow myelopoiesis and increased Mo production as well as extrinsic and intrinsic factors that...Continue Reading

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Citations

Oct 13, 2020·Frontiers in Endocrinology·Jorge A Berlanga-AcostaPedro A Valdés-Sosa
Feb 12, 2021·Frontiers in Cell and Developmental Biology·Miya KangLyndon F Cooper
Mar 2, 2021·International Journal of Pharmaceutics·Katie GloverDimitrios A Lamprou
Apr 4, 2021·International Journal of Molecular Sciences·Yevgeniy KimArman Saparov
Jun 30, 2021·Seminars in Cell & Developmental Biology·Sonya J WolfKatherine Gallagher
Jul 6, 2021·Frontiers in Immunology·Meirong LiXiaobing Fu

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Methods Mentioned

BETA
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