Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19.

Nature Immunology
Enrico BrunettaAlberto Mantovani

Abstract

Long pentraxin 3 (PTX3) is an essential component of humoral innate immunity, involved in resistance to selected pathogens and in the regulation of inflammation1-3. The present study was designed to assess the presence and significance of PTX3 in Coronavirus Disease 2019 (COVID-19)4-7. RNA-sequencing analysis of peripheral blood mononuclear cells, single-cell bioinformatics analysis and immunohistochemistry of lung autopsy samples revealed that myelomonocytic cells and endothelial cells express high levels of PTX3 in patients with COVID-19. Increased plasma concentrations of PTX3 were detected in 96 patients with COVID-19. PTX3 emerged as a strong independent predictor of 28-d mortality in multivariable analysis, better than conventional markers of inflammation, in hospitalized patients with COVID-19. The prognostic significance of PTX3 abundance for mortality was confirmed in a second independent cohort (54 patients). Thus, circulating and lung myelomonocytic cells and endothelial cells are a major source of PTX3, and PTX3 plasma concentration can serve as an independent strong prognostic indicator of short-term mortality in COVID-19.

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Jan 23, 2021·Cell Death and Differentiation·Guido ForniUNKNOWN COVID-19 Commission of Accademia Nazionale dei Lincei, Rome
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Datasets Mentioned

BETA
GSE147507
GSE145926
GSE150728

Methods Mentioned

BETA
RNA-seq
scRNA-seq
Assay
ELISA

Software Mentioned

Rmagic
bcl2fastq2
R library
RStudio
Bioconductor
SingleR
DESeq2
GENCODE
Seurat
ggplot2

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