PMID: 11169214Feb 13, 2001Paper

Macrophage heterogeneity, antigen presentation, and membrane fluidity: implications in visceral Leishmaniasis

Scandinavian Journal of Immunology
E SenS Roy

Abstract

Morphological and functional heterogeneity of the splenic macrophage (M phi) population was studied in Leishmania donovani (LD) infected BALB/c mice. On a discontinuous percoll gradient two distinct M phi populations were separated. They differed significantly in size as evident from Scanning Electron Microscopy (SEM). Morphologically, the bigger M phi (LM) showed surface projections, whereas the smaller M phi (SM) was round. As regards the antigen-presenting abilities, the LM of infected animals showed defective antigen-presenting abilities at a later stage of the disease, i.e. 6 months post infection ((6)I-LM) but not earlier, whereas the SM population remained functionally intact throughout the course of the infection. Further, the (6)I-LM showed a much enhanced Ad status as compared to their controls. Interestingly, both the (6)I-LM and the control set showed a comparable level of binding of a known A(d) restricted peptide. Despite the presence of sufficient A(d) molecules and the ability to bind the appropriate peptide, (6)I-LM were unable to stimulate peptide specific T-cell hybridoma. Further, the (6)I-LM showed an increase in membrane fluidity and distorted morphology with membrane fissure and blebs as evident from SEM....Continue Reading

References

Apr 1, 1979·European Journal of Immunology·T SpringerC Milstein
Jun 1, 1991·Current Opinion in Immunology·G A van SeventerS Shaw
May 5, 1989·Science·S RoyM L Gefter
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L D FaloK L Rock
Sep 1, 1983·Reviews of Infectious Diseases·R D PearsonH D Kay
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H J Heiniger, J D Marshall
Nov 1, 1980·European Journal of Immunology·M P DabrowskiA E Thomson
Dec 1, 1993·Immunology Today·L M Schwartz, B A Osborne
Feb 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T R RingroseR Wilkinson
Mar 20, 1998·Clinical Science·M A DevynckJ Zicha
May 23, 1998·The International Journal of Biochemistry & Cell Biology·B C KonerD Dash
Mar 3, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·N AhmadD L Laskin

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Citations

Dec 7, 2007·Antimicrobial Agents and Chemotherapy·Jayati Mookerjee BasuSyamal Roy
Nov 2, 2011·The Veterinary Clinics of North America. Small Animal Practice·Yvonne DrechslerPedro Paulo V P Diniz
Dec 23, 2006·Trends in Parasitology·Thomas J Pucadyil, Amitabha Chattopadhyay
Jul 11, 2006·Microbes and Infection·Nicolas ColtelGeorges E Grau
Apr 10, 2010·Biology of the Cell·Flávia Sarmento VieiraRobson Coutinho-Silva
Jan 30, 2014·Revista Da Sociedade Brasileira De Medicina Tropical·Mariana GattoSueli Aparecida Calvi
Aug 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Debabani ChakrabortySyamal Roy
Dec 13, 2006·The American Journal of Clinical Nutrition·Saame Raza Shaikh, Michael Edidin
Dec 10, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Courtney L MeierPaul M Kaye
Aug 28, 2020·Frontiers in Cellular and Infection Microbiology·Sheetal Saini, Ambak Kumar Rai
Sep 19, 2007·Molecular Cancer Therapeutics·Vivek SharmaEllora Sen
Mar 16, 2021·Frontiers in Nutrition·Sheetal Saini, Ambak Kumar Rai
Mar 24, 2021·Parasite Immunology·Supratim PradhanBudhaditya Mukherjee

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