Abstract
The clinical presentation of 71 untreated patients with Hodgkin's disease was studied in relation to immunohistochemically demonstrable lysozyme in the lymph node biopsy material. Sixty-one patients (86%) showed a positive staining reaction of varying degree, while ten (14%) showed no demonstrable lysozyme. The clinical features of lysozyme-positive patients differed markedly from those of lysozyme-negative patients. Stain-positive patients were younger (29 vs. 46), were more often in clinical Stage I or II disease (69% vs. 10%, P less than 0.001), and less frequently had constitutional symptoms (34% vs. 70%, P less than 0.02). Moreover, within the stain-positive group, patients who had the most intense staining reaction (mottling pattern) also had the most favorable clinical and histopathologic features at the time of diagnosis. The observations suggest that in Hodgkin's disease the lysozyme secretory activity of macrophage-histiocytes may be an important element of host resistance to neoplasia and that a depression of this secretory activity corresponds with disseminated disease.
References
Jun 1, 1977·The Journal of Experimental Medicine·J C LongL Atkins
May 15, 1978·International Journal of Cancer. Journal International Du Cancer·C S PapadimitriouK Lennert
Nov 30, 1978·The New England Journal of Medicine·M E KadinR Warnke
Jul 1, 1979·The Journal of Clinical Investigation·L I GordonH S Jacob
Oct 15, 1977·Experientia·R C Curran, J Gregory
Feb 1, 1979·Scandinavian Journal of Haematology·N E Hansen, H Karle
May 1, 1978·Cancer·L Leb, J A Merritt
Jan 1, 1976·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C R Taylor
Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·H S Kaplan, S Gartner
Feb 1, 1975·Journal of Clinical Pathology·D Y Mason, C R Taylor
Feb 20, 1975·The New England Journal of Medicine·K R FalchukK J Isselbacher
Jan 1, 1971·Acta Haematologica·E Syrén, A M Raeste
Apr 1, 1973·The American Journal of the Medical Sciences·P E PerillieS C Finch
Jun 8, 1973·Nature·E F OssermanR E Fischel
Feb 1, 1972·Australian and New Zealand Journal of Medicine·F C Firkin
Apr 1, 1973·Cancer·J A LeviF W Gunz
May 1, 1974·The Journal of Experimental Medicine·S GordonZ A Cohn
Oct 1, 1968·Journal of Bacteriology·L A Wilson, J K Spitznagel
Aug 1, 1969·Science·D M Chipman, N Sharon
Nov 1, 1966·The Journal of Experimental Medicine·E F Osserman, D P Lawlor
Nov 1, 1971·British Journal of Haematology·D CatovskyC Griffin
Feb 1, 1968·Proceedings of the Society for Experimental Biology and Medicine·M E Fink, S C Finch
Jan 1, 1981·Human Pathology·H J ReeH Fanger
Citations
Oct 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·D M Goldberg, D Brown
Mar 1, 1983·Journal of Clinical Pathology·R J Sokol, G Hudson
Dec 1, 1985·Cancer·T FurukawaK Suemasu
Oct 1, 1987·Cancer·H J Ree
Jul 1, 1986·Cancer·H J Ree
Oct 1, 1982·Immunology Today·R K Kumar, R Penny
Dec 1, 1983·Cancer·R Mir, L B Kahn
Jul 15, 1983·Cancer·H J Ree, J P Crowley
Sep 1, 1981·Scandinavian Journal of Haematology·N E HansenP Christoffersen