Macrophage immunomodulation: An indispensable tool to evaluate the performance of wound dressing biomaterials

Journal of Applied Biomaterials & Functional Materials
Patrícia VarelaGianluca Ciardelli

Abstract

A major burden of the healthcare system resides in providing proper medical treatment for all types of chronic wounds, which are usually treated with dressings to induce a faster regeneration. Hence, to reduce healing time and improve the patient's quality of life, it is extremely important to select the most appropriate constituent material for a specific wound dressing. A wide range of wound dressings exist but their mechanisms of action are poorly explored, especially concerning the immunomodulatory effects that occur from the interactions between immune cells and the biomaterial. Tissue-resident and monocyte-derived recruited macrophages are key regulators of wound repair. These phagocytic immune cells exert specific functions during the different stages of wound healing. The recognition of the substantial role of macrophages in the outcome of the wound healing process requires specific understanding of the immunomodulatory effects of commercially available or newly developed wound dressings. For a precise intervention, it is necessary to obtain more knowledge on macrophage polarization in different phases of wound healing in the presence of the dressings. The main purpose of this review is to collect clinical cases in whic...Continue Reading

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Citations

Jun 9, 2020·Experimental and Therapeutic Medicine·Chao Liu, Jiao Sun
Jul 6, 2021·Frontiers in Immunology·Meirong LiXiaobing Fu
Sep 9, 2019·ACS Biomaterials Science & Engineering·Serena MandlaMilica Radisic

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