Macrophage inflammatory protein-2 contributes to liver resection-induced acceleration of hepatic metastatic tumor growth

World Journal of Gastroenterology : WJG
Otto KollmarMartin K Schilling

Abstract

To study the role of macrophage inflammatory protein (MIP)-2 in liver resection-induced acceleration of tumor growth in a mouse model of hepatic metastasis. After a 50% hepatectomy, 1x10(5) CT26.WT cells were implanted into the left liver lobe of syngeneic balb/c mice (PHx). Additional animals were treated with a monoclonal antibody (MAB452) neutralizing MIP-2 (PHx+mAB). Non-resected and non-mAB-treated mice (Con) served as controls. After 7 d, tumor angiogenesis and microcirculation as well as cell proliferation, tumor growth, and CXCR-2 expression were analyzed using intravital fluorescence microscopy, histology, immunohistochemistry, and flow cytometry. Partial hepatectomy increased (P<0.05) the expression of the MIP-2 receptor CXCR-2 on tumor cells when compared with non-resected controls, and markedly accelerated (P<0.05) angiogenesis and metastatic tumor growth. Neutralization of MIP-2 by MAB452 treatment significantly (P<0.05) depressed CXCR-2 expression. Further, the blockade of MIP-2 reduced the angiogenic response (P<0.05) and inhibited tumor growth (P<0.05). Of interest, liver resection-induced hepatocyte proliferation was not effected by anti-MIP-2 treatment. MIP-2 significantly contributes to liver resection-induce...Continue Reading

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Citations

May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Barbara DallerThomas Hehlgans
Jan 30, 2007·Clinical & Experimental Metastasis·Kathrin RupertusMartin K Schilling
Nov 18, 2011·Langenbeck's Archives of Surgery·Maximilian von HeesenOtto Kollmar
Mar 2, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sejo OhSung K Moon
Oct 13, 2009·International Journal of Cancer. Journal International Du Cancer·Otto KollmarMartin K Schilling
May 24, 2017·World Journal of Gastroenterology : WJG·Chao-Chao QinZhi Chen
Jan 9, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Christopher ChristophiTheodora Fifis
Apr 26, 2013·Disease Models & Mechanisms·Miriam R Fein, Mikala Egeblad

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