PMID: 9187960Apr 1, 1997Paper

Macrophage-mediated candidacidal activity is augmented by exposure to eosinophil peroxidase: a paradigm for eosinophil-macrophage interaction

Inflammation
D L LefkowitzR C Allen

Abstract

Various disease states are associated with eosinophilia and the release of eosinophil peroxidase (EPO) into the microenvironment. The present study targets the effects of low levels of EPO on macrophage (M phi) phagocytosis and intracellular killing of Candida albicans as well as M phi oxidative activity measured as the luminescence product of luminol dioxygenation. Resident murine peritoneal M phi were exposed to various concentrations of EPO. Chemiluminescence data indicate that nanomolar concentrations of EPO markedly enhanced the dioxygenation activity (respiratory burst) of M phi. In other studies, the exposure of M phi to 0.17 microM EPO for 10 min. enhanced M phi-mediated candidacidal activity 10 fold. The above data indicate that EPO enhances certain M phi functions. Also the results illustrate a previously un-recognized interaction between eosinophils and M phi and implicate yet another possible role for EPO in host defenses against disease.

Citations

Jul 29, 1999·Luminescence : the Journal of Biological and Chemical Luminescence·J FäldtC Dahlgren
Apr 22, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Alejandro RodríguezJosé Meseguer
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·K L DenzlerN A Lee
Jan 1, 2014·Infection and Immunity·Lauren M LillyChad Steele
Jul 23, 1999·Infection and Immunity·V BorelliG Zabucchi
Jun 30, 2000·Cellular Immunology·D L LefkowitzS S Lefkowitz
Feb 26, 2000·International Journal of Immunopharmacology·D L LefkowitzS S Lefkowitz
Oct 26, 2016·Microbiology Spectrum·Ting Wen, Marc E Rothenberg
Oct 26, 2005·Microbes and Infection·Sueli de Oliveira SilvaAna Campa

❮ Previous
Next ❯

Related Concepts

Related Feeds

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.