Macrophage-mediated inflammation and glial response in the skeletal muscle of a rat model of familial amyotrophic lateral sclerosis (ALS)

Experimental Neurology
Jonathan M Van DykeMasatoshi Suzuki

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by progressive motor dysfunction and loss of large motor neurons in the spinal cord and brain stem. While much research has focused on mechanisms of motor neuron cell death in the spinal cord, degenerative processes in skeletal muscle and neuromuscular junctions (NMJs) are also observed early in disease development. Although recent studies support the potential therapeutic benefits of targeting the skeletal muscle in ALS, relatively little is known about inflammation and glial responses in skeletal muscle and near NMJs, or how these responses contribute to motor neuron survival, neuromuscular innervation, or motor dysfunction in ALS. We recently showed that human mesenchymal stem cells modified to release glial cell line-derived neurotrophic factor (hMSC-GDNF) extend survival and protect NMJs and motor neurons in SOD1(G93A) rats when delivered to limb muscles. In this study, we evaluate inflammatory and glial responses near NMJs in the limb muscle collected from a rat model of familial ALS (SOD1(G93A) transgenic rats) during disease progression and following hMSC-GDNF transplantation. Muscle samples were collected from pre-symptomatic, sympto...Continue Reading

References

Dec 1, 1994·Agents and Actions·J F BorelH Stähelin
Jan 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·David S HowlandJeffrey D Rothstein
Jan 23, 2004·Experimental Neurology·Lindsey R FischerJonathan D Glass
Jun 3, 2006·Science·Séverine BoilléeDon W Cleveland
Mar 17, 2007·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Masatoshi SuzukiClive N Svendsen
Jun 1, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hyuno KangWesley Thompson
Jun 24, 2008·Annals of the New York Academy of Sciences·Zhihua Feng, Chien-Ping Ko
Sep 18, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Masatoshi SuzukiClive N Svendsen
Apr 24, 2009·Current Opinion in Pharmacology·Luc Dupuis, Jean-Philippe Loeffler
Jun 18, 2009·Muscle & Nerve·Francesca NotturnoAntonino Uncini
Nov 26, 2009·Proceedings of the National Academy of Sciences of the United States of America·Isaac M ChiuMichael C Carroll
Dec 9, 2009·Free Radical Biology & Medicine·Siân C Barber, Pamela J Shaw
Apr 22, 2010·CNS & Neurological Disorders Drug Targets·E BogaertL Van Den Bosch
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Felix MeissnerArturo Zychlinsky
Dec 24, 2010·Brain, Behavior, and Immunity·David R BeersJenny S Henkel
Feb 9, 2011·Neuropathology and Applied Neurobiology·L M DuffyA J Grierson
Mar 14, 2012·Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases·Antonio Hayes-PunzoMasatoshi Suzuki
Apr 21, 2012·Current Molecular Medicine·M P De MiguelF Arnalich-Montiel
Aug 25, 2012·Neurology Research International·Dan KrakoraMasatoshi Suzuki
Nov 1, 2012·Molecular and Cellular Neurosciences·M C EvansM R Turner
May 16, 2013·Acta Neuropathologica·Anna M BlokhuisR Jeroen Pasterkamp
May 29, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dan KrakoraMasatoshi Suzuki
Mar 13, 2014·Frontiers in Cellular Neuroscience·Luis B Tovar-Y-RomoRicardo Tapia
May 3, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hyuno KangWesley J Thompson
Jun 27, 2014·Mediators of Inflammation·Gabriel Olmos, Jerònia Lladó
Sep 7, 2014·Biochimica Et Biophysica Acta·Senda Ajroud-Driss, Teepu Siddique
May 2, 2015·The Journal of Clinical Investigation·Owen M PetersRobert H Brown
May 16, 2015·Trends in Neurosciences·Zhihui Yang, Kevin K W Wang

❮ Previous
Next ❯

Citations

Dec 4, 2019·Journal of Cellular Physiology·Misagh RajabinejadAlireza Rezaiemanesh
Jun 24, 2020·Stem Cells Translational Medicine·Bogna BadyraMarcin Majka
Oct 31, 2017·Mediators of Inflammation·Massimo TortaroloCaterina Bendotti
May 7, 2020·Frontiers in Neurology·Pamela A McCombeRobert D Henderson
Jul 24, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Sunjung Park, Eun Jin Yang
Apr 10, 2019·CNS & Neurological Disorders Drug Targets·Lian LiHua She
Sep 29, 2020·British Journal of Pharmacology·Raquel ManzanoRosario Osta
Jan 11, 2021·Molecular and Cellular Neurosciences·Rachel RiosAlison K Snyder-Warwick
Jan 1, 2021·Journal of Neurochemistry·Rianne de JonghR Jeroen Pasterkamp
Apr 4, 2021·International Journal of Molecular Sciences·Leticia Moreno-GarcíaRosario Osta
Apr 13, 2021·Frontiers in Cellular Neuroscience·Maria Puigdomenech-PochRubèn López-Vales
Nov 3, 2016·Journal of Cell Science·Emma L BastowCampbell W Gourlay
Jun 10, 2021·Scientific Reports·Ying SiPeter H King

❮ Previous
Next ❯

Related Concepts

Related Feeds

ALS: Genetics

Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. ALS is a genetically heterogeneous disorder with several causative genes. Here are the latest discoveries pertaining to the genetics of this disease.

ALS: Genetics

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating genetic alterations in this genetically heterogeneous disorder.

ALS: Pathogenic Mechanisms

Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disorder characterized by muscle weakness. Here is the latest research investigating pathogenic mechanisms that underlie this genetically heterogeneous disorder.

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.