Macrophage mediation in normal and diabetic wound healing responses

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Goutham V Ganesh, Kunka Mohanram Ramkumar

Abstract

The failure in timely healing of wounds is a central feature in chronic wounds that leads to physiological, psychological and economic burdens. Macrophages have been demonstrated to have various functions in wounds including host defense, the promotion and resolution of inflammation, the removal of apoptotic cells and tissue restoration following injury. Accumulated evidence suggests that macrophage dysfunction is a component of the pathogenesis of non-healing wounds. While the overall signaling cascades have been well understood, their complex interplay and a detailed characterization of events that are disrupted in chronic wounds have still not emerged satisfactorily. The existing literature was reviewed to summarize the regulation of macrophage polarization in wound closure and dysregulation in non-healing wounds. Further, the review also underscored the role of Nrf2 in promoting macrophage-mediated regulation in wound responses and in particular, macrophage involvement in iron homeostasis that is impaired in chronic wounds such as in diabetes. The mechanisms involved in the reprogramming of macrophage subtypes in chronic wounds are still emerging. Furthermore, treating non-healing wounds has increasingly been shifting focus...Continue Reading

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Citations

May 14, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Beata SadowskaBarbara Różalska
Jan 8, 2021·Journal of Translational Medicine·Bibi S SubhanPiul S Rabbani
Jun 6, 2021·Translational Research : the Journal of Laboratory and Clinical Medicine·Amanda E LouiselleKenneth W Liechty
Jul 14, 2021·Experimental Gerontology·Goutham V Ganesh, Kunka Mohanram Ramkumar

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Methods Mentioned

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