Macrophage mesenchymal migration requires podosome stabilization by filamin A.

The Journal of Biological Chemistry
Romain GuietIsabelle Maridonneau-Parini

Abstract

Filamin A (FLNa) is a cross-linker of actin filaments and serves as a scaffold protein mostly involved in the regulation of actin polymerization. It is distributed ubiquitously, and null mutations have strong consequences on embryonic development in humans, with organ defects which suggest deficiencies in cell migration. We have reported previously that macrophages, the archetypal migratory cells, use the protease- and podosome-dependent mesenchymal migration mode in dense three-dimensional environments, whereas they use the protease- and podosome-independent amoeboid mode in more porous matrices. Because FLNa has been shown to localize to podosomes, we hypothesized that the defects seen in patients carrying FLNa mutations could be related to the capacity of certain cell types to form podosomes. Using strategies based on FLNa knock-out, knockdown, and rescue, we show that FLNa (i) is involved in podosome stability and their organization as rosettes and three-dimensional podosomes, (ii) regulates the proteolysis of the matrix mediated by podosomes in macrophages, (iii) is required for podosome rosette formation triggered by Hck, and (iv) is necessary for mesenchymal migration but dispensable for amoeboid migration. These new fun...Continue Reading

References

Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S D WrightJ D Loike
Mar 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·Y OhtaT P Stossel
Sep 1, 2000·The Journal of Biological Chemistry·S CarrénoI Maridonneau-Parini
Oct 30, 2001·The Journal of Biological Chemistry·Florence C GuibalYvon E Cayre
Jan 10, 2002·Nature Cell Biology·D A CalderwoodM H Ginsberg
Jan 12, 2002·The Journal of Biological Chemistry·Fumihiko NakamuraThomas P Stossel
Mar 21, 2002·The Journal of Biological Chemistry·Sébastien CarrénoIsabelle Maridonneau-Parini
Feb 19, 2003·Biochemical and Biophysical Research Communications·Kozue UedaHiroshi Hosoya
Mar 4, 2003·Nature Genetics·Stephen P RobertsonUNKNOWN OPD-spectrum Disorders Clinical Collaborative Group
Sep 16, 2003·Molecular and Cellular Biology·Violaine MoreauElisabeth Génot
Oct 29, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Takashi NaganoMakoto Sato
Nov 2, 2004·Nature Cell Biology·Yuanyi Feng, Christopher A Walsh
May 27, 2005·Current Opinion in Genetics & Development·Stephen P Robertson
Jul 6, 2005·Epilepsy & Behavior : E&B·Jie Lu, Volney Sheen
Jul 7, 2005·Traffic·Céline CougouleIsabelle Maridonneau-Parini
Sep 16, 2005·American Journal of Physiology. Cell Physiology·Shutang ZhouAlan S Mak
Feb 4, 2006·Molecular Cell·Tiila KiemaDavid A Calderwood
Feb 8, 2006·The Journal of Biological Chemistry·Marilena MarziaWilliam C Horne
May 15, 2007·The Journal of Biological Chemistry·Claire VincentArnaud Labrousse
May 16, 2007·Journal of Cellular Physiology·Renaud PoinclouxVéronique Le Cabec
Sep 28, 2007·Molecular Biology of the Cell·Anne ChabadelFrédéric Saltel
Nov 6, 2007·Molecular Biology of the Cell·Olivier DestaingRoland Baron
Nov 30, 2007·Molecular Biology of the Cell·Cédric BadowskiMarc R Block
Jan 19, 2008·Trends in Neurosciences·Matthew R SarkisianPasko Rakic
Jun 10, 2008·Nature Methods·Julia RiedlRoland Wedlich-Soldner
Sep 19, 2008·Blood·Mélina L HeuzéPierre G Lutz
May 22, 2009·Molecular Biology of the Cell·Scott GehlerPatricia J Keely
Nov 6, 2009·Journal of Cell Science·Patricia RottiersElisabeth Génot
Nov 26, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roland LeungMichael Glogauer
Dec 19, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emeline Van GoethemVéronique Le Cabec
Jan 12, 2010·Trends in Cell Biology·Alex-Xianghua ZhouLevent M Akyürek
May 22, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christel VérolletIsabelle Maridonneau-Parini
Aug 31, 2010·European Journal of Cell Biology·Emeline Van GoethemVéronique Le Cabec
Sep 11, 2010·Current Opinion in Cell Biology·Victoria Sanz-Moreno, Christopher J Marshall
Oct 13, 2010·The Journal of Experimental Medicine·Yingjie XuMoulay A Alaoui-Jamali
Nov 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anna LabernadieGuillaume M Charrière
Nov 26, 2010·FEBS Letters·Hugh Kim, Christopher A McCulloch
Dec 21, 2010·Cell Adhesion & Migration·Fumihiko NakamuraJohn H Hartwig
Jan 12, 2011·Current Neurology and Neuroscience Reports·Judy S Liu
Feb 18, 2011·Genesis : the Journal of Genetics and Development·Pilar Cejudo-Martin, Sara A Courtneidge

❮ Previous
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Citations

May 2, 2013·Blood·Isabelle LamsoulPierre G Lutz
Feb 8, 2013·Cell & Bioscience·Jingyin YueZhiyuan Shen
May 19, 2012·Journal of Cell Science·Massimiliano BaldassarreDavid A Calderwood
Jan 5, 2013·International Journal of Biological Sciences·Xi JiangZhiyuan Shen
Jun 4, 2014·Immunology and Cell Biology·Anthony TroegelerGeanncarlo Lugo-Villarino
Apr 20, 2013·European Journal of Cell Biology·Heiani TouaitahuataGeraldine Pawlak
Sep 25, 2012·European Journal of Cell Biology·Céline CougouleIsabelle Maridonneau-Parini
Jul 25, 2012·European Journal of Cell Biology·Lindsy R Boateng, Anna Huttenlocher
Dec 4, 2015·European Journal of Immunology·Inés C Osma-GarciaManuel D Díaz-Muñoz
Oct 27, 2015·Frontiers in Immunology·Christel VérolletIsabelle Maridonneau-Parini
Oct 17, 2014·Immunological Reviews·Isabelle Maridonneau-Parini
Feb 7, 2015·Cytoskeleton·Kyonghee SonElizabeth J Luna
Dec 21, 2014·Blood·Christel VérolletIsabelle Maridonneau-Parini
Apr 26, 2014·Blood·Isabelle Maridonneau-Parini
Oct 11, 2014·Cellular and Molecular Life Sciences : CMLS·Stefan Linder, Christiane Wiesner
Oct 8, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Liisa M UotilaSusanna C Fagerholm
Jan 8, 2019·Advanced Healthcare Materials·Jeong-Ki KimDong-Hwee Kim
Jun 8, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christel VérolletIsabelle Maridonneau-Parini
Apr 23, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Theres FeyAndreas Dendorfer
Nov 30, 2018·Biomaterials Science·Vladimir Mulens-AriasFlorence Gazeau
Jun 20, 2019·Journal of Muscle Research and Cell Motility·Brian SitThomas Iskratsch
May 16, 2018·Frontiers in Immunology·Céline CougouleIsabelle Maridonneau-Parini
Dec 29, 2017·Molecular Biology of the Cell·Natalya G DulyaninovaAnne R Bresnick
Apr 10, 2014·Cell Adhesion & Migration·Christiane WiesnerStefan Linder
Dec 15, 2019·Journal of Cell Science·Koen van den DriesRenaud Poincloux
Jun 25, 2019·Bone·Brigitte Raynaud-MessinaIsabelle Maridonneau-Parini
Jan 25, 2020·European Journal of Medical Genetics·Benjamin DurandSalima El Chehadeh
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Isabelle LamsoulPierre G Lutz
Feb 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wan-Jiao GaoHua Zhou
Mar 23, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Wan-Jiao GaoHua Zhou
Mar 31, 2019·The American Journal of Pathology·Patricia J BrooksChristopher A McCulloch
Feb 26, 2021·Journal of Virology·Wei LiZongqiang Cui
Mar 26, 2013·Journal of Cell Science·Tomasz J Proszynski, Joshua R Sanes

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