PMID: 11920501Mar 29, 2002Paper

Macrophage migration inhibitory factor evaluation compared with prostate specific antigen as a biomarker in patients with prostate carcinoma

Cancer
Katherine L Meyer-SieglerMyron Tannenbaum

Abstract

Cytokines are polypeptides that constitute a class of chemical mediator molecules that modulate cell growth by inducing specific target gene expression. The objective of this study was to evaluate the clinical usefulness of serum evaluation of the cytokine macrophage migration inhibitory factor (MIF) in patients undergoing routine prostate specific antigen (PSA) screening. In this preliminary, retrospective study, the authors report the development of an enzyme-linked immunosorbent assay (ELISA) for MIF determination in serum samples. A polymerase chain reaction (PCR)-based assay investigated associations between MIF expression and prostate carcinoma (CaP). The authors developed a relative quantitative reverse transcriptase-PCR assay to determine MIF mRNA amounts within laser-capture microscopy (LCM)-dissected prostate epithelial cells. A comparison of serum MIF levels and total PSA levels identified a positive correlation (correlation coefficient [r2] = 0.61; P < 0.001; n = 509 patients), suggesting an association between elevated serum concentrations of these proteins and CaP. A correlation of serum MIF levels with a diagnosis of CaP demonstrated that patients with a previous CaP diagnosis had significantly elevated serum MIF...Continue Reading

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Citations

Nov 11, 2003·Cellular Signalling·Robert A Mitchell
Mar 9, 2005·Trends in Cell Biology·Weigang WangJohn S Condeelis
Oct 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·K Meyer-Siegler
Feb 26, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Katherine L Meyer-SieglerPedro L Vera
Jun 4, 2010·Drug News & Perspectives·Gerrit GriebRichard Bucala
Mar 7, 2014·British Journal of Cancer·C OtterstromV Serre-Beinier
May 21, 2014·Proceedings of the National Academy of Sciences of the United States of America·Olivia TwuPatricia J Johnson
May 1, 2008·Expert Opinion on Medical Diagnostics·Joel Lanoix, Eustache Paramithiotis
Jan 1, 2010·Expert Opinion on Medical Diagnostics·Joanna M Hunter, Eustache Paramithiotis
Jan 19, 2016·Medicinal Research Reviews·Ciaran O'ReillySeamas C Donnelly
Feb 3, 2009·Experimental and Molecular Pathology·Beatriz E RendonRobert A Mitchell
May 29, 2009·Journal of Surgical Oncology·G X DingL X Hua
May 15, 2003·The Prostate·Angelita G UtlegBiaoyang Lin
Apr 15, 2014·Biochimica Et Biophysica Acta·Carsten StephanKlaus Jung
May 28, 2013·Free Radical Biology & Medicine·Julia SobierajskiTienush Rassaf
May 4, 2017·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Dik-Lung MaChung-Hang Leung
Apr 1, 2005·World Journal of Gastroenterology : WJG·Harry Hua-Xiang XiaBenjamin Chun-Yu Wong
Feb 18, 2016·Oncotarget·Cintia D'Amato-BritoVéronique Serre-Beinier
Feb 26, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sofia LourencoSam M Janes
Dec 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Katherine L Meyer-SieglerPedro L Vera
May 21, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mathias KrockenbergerJörg Wischhusen

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