Macrophage migration inhibitory factor expression in cervical cancer.

Journal of Cancer Research and Clinical Oncology
Mathias KrockenbergerArnd Honig

Abstract

The glycoprotein macrophage migration inhibitory factor (MIF) is a cytokine that has been shown to promote tumor progression and tumor immune escape in ovarian cancer. The present study investigates MIF in uterine cervical cancer. Eighty surgical biopsies (32 cervical dysplasias, 23 in situ carcinomas and 25 invasive carcinomas) of uterine cervical tissue were evaluated immunohistochemically for MIF expression. In uterine cervical cancer cell lines SiHa and CaSki and their respective supernatants, MIF protein expression was analyzed by Western blotting, enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase polymerase chain reaction (RT-PCR). Immunohistochemical analysis shows that MIF is clearly overexpressed on the protein level in invasive cervical cancer compared to cervical dysplasias. MIF overexpression was confirmed by RT-PCR in surgical biopsies of invasive cervical cancer. Western blotting reveals that the MIF protein is overexpressed in SiHA und CaSki cervical cancer cell lines, whereas the ELISA reveals that cervical cancer cells secrete MIF. MIF has been shown to promote tumor immune escape mechanisms in other cancer entities, which makes it an interesting target for cancer therapy, given the known sign...Continue Reading

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Citations

Mar 26, 2014·Journal of Cancer Research and Clinical Oncology·Nadège KindtSven Saussez
Jan 29, 2013·Journal of Cancer Research and Clinical Oncology·Nadège KindtSven Saussez
Oct 25, 2016·Pathology Oncology Research : POR·Camila Cristina Guimarães NobreJosé Veríssimo Fernandes
Jul 28, 2011·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Rong-Jie ChengYan Fu
Jul 10, 2019·International Journal of Molecular Sciences·Qun WangHelene Heidegger
Dec 3, 2011·Molecular BioSystems·Francesca GuidiLuigi Messori
Nov 11, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Yunxiang ZhouYongchuan Deng

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