Macrophage migration inhibitory factor (MIF) in chinese amphioxus as a molecular marker of immune evolution during the transition of invertebrate/vertebrate

Developmental and Comparative Immunology
Jingchun DuAnlong Xu

Abstract

Macrophage migration inhibitory factor (MIF) is an important cytokine related to host defenses and autoimmune diseases. Here, we reported two full-length cDNA clones isolated from Chinese amphioxus (Branchiostoma belcheri tsingtaunese). Amino acid sequences analysis and structure prediction of these two molecules, called Bbt-MIF-I and Bbt-MIF-II, respectively, indicated that several conservative domains existed in the two amphioxus MIFs and their sequences were highly homologous to their counterparts of other species. Intriguingly, the Bbt-MIFs gene is present in multi-copy per haploid genome, which is very unusual compared with vertebrate's MIF gene given the known genome duplication theory. The genomic copy number, expression pattern of MIF gene and phylogenetic analysis of MIF proteins all suggested that a leap forward happened for MIF gene during the evolution from invertebrate to vertebrate. Considering the crucial role of MIF in innate immunity, MIF might serve as one of key molecular markers of evolution of immune system.

References

Sep 1, 1992·Molecular and Cellular Biology·A LanahanD Nathans
Jul 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·J R David
Aug 18, 1994·Nature·J Garcia-Fernández, P W Holland
Apr 1, 1994·Computer Applications in the Biosciences : CABIOS·S KumarM Nei
Jul 23, 1996·Proceedings of the National Academy of Sciences of the United States of America·M BacherR Bucala
Apr 16, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·J BernhagenR Bucala
May 15, 1998·Molecular Biology and Evolution·N A Williams, P W Holland
Jun 24, 1998·The Journal of Clinical Investigation·A G RossiS C Donnelly
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·T CalandraR Bucala
Jan 20, 1999·The Journal of Experimental Medicine·M BozzaJ R David
Jun 8, 1999·Annual Review of Immunology·G W LitmanJ P Rast
Sep 14, 1999·The Journal of Allergy and Clinical Immunology·T ShimizuJ Nishihira
Nov 24, 1999·The Journal of Experimental Medicine·J D HudsonD H Beach
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·S M Shimeld, P W Holland
Oct 6, 2000·Molecular Biology and Evolution·N A Williams, P W Holland
Nov 22, 2000·The Journal of Clinical Investigation·F BenigniR Bucala
Dec 26, 2001·Bioinformatics·S KumarM Nei
Mar 14, 2002·Critical Care Medicine·John A. Baugh, Richard Bucala
Apr 5, 2002·Microbes and Infection·Hongqi LueJürgen Bernhagen
Nov 19, 2002·Biochemical and Biophysical Research Communications·Chun-yan MouAn-long Xu
Nov 26, 2002·Nature Immunology·Jim Kaufman
Jun 5, 2003·The Journal of Experimental Medicine·Lin LengRichard Bucala
Sep 23, 2003·Nature Reviews. Immunology·Thierry Calandra, Thierry Roger
Oct 17, 2003·Development·Carolina MinguillónJordi Garcia-Fernàndez

❮ Previous
Next ❯

Citations

Jun 1, 2014·Developmental and Comparative Immunology·Shaochun YuanAnlong Xu
Apr 20, 2007·Developmental and Comparative Immunology·Hong-Jian JinJian-Zhong Shao
Apr 23, 2016·Developmental and Comparative Immunology·Linhu Zou, Baozhong Liu
Apr 27, 2016·Developmental and Comparative Immunology·A RomeroA Figueras
Jul 6, 2017·Experimental Neurology·Marcel F Leyton-JaimesAdrian Israelson
Jan 3, 2021·Developmental and Comparative Immunology·Wenjun WangShuo Ding

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.