PMID: 11932196Apr 5, 2002Paper

Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease

Microbes and Infection
Hongqi LueJürgen Bernhagen

Abstract

Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of host defenses with a role in septic shock and chronic inflammatory and autoimmune diseases. Its mechanism of action is incompletely understood. Here, we attempt to correlate current knowledge on the molecular pathways of MIF activity with its functions in immunity and disease.

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