Macrophage-NLRP3 Inflammasome Activation Exacerbates Cardiac Dysfunction after Ischemic Stroke in a Mouse Model of Diabetes.

Neuroscience Bulletin
Hong-Bin LinHong-Fei Zhang

Abstract

Ischemic stroke is one of the leading causes of death worldwide. In the post-stroke stage, cardiac dysfunction is common and is known as the brain-heart interaction. Diabetes mellitus worsens the post-stroke outcome. Stroke-induced systemic inflammation is the major causative factor for the sequential complications, but the mechanism underlying the brain-heart interaction in diabetes has not been clarified. The NLRP3 (NLR pyrin domain-containing 3) inflammasome, an important component of the inflammation after stroke, is mainly activated in M1-polarized macrophages. In this study, we found that the cardiac dysfunction induced by ischemic stroke is more severe in a mouse model of type 2 diabetes. Meanwhile, M1-polarized macrophage infiltration and NLRP3 inflammasome activation increased in the cardiac ventricle after diabetic stroke. Importantly, the NLRP3 inflammasome inhibitor CY-09 restored cardiac function, indicating that the M1-polarized macrophage-NLRP3 inflammasome activation is a pathway underlying the brain-heart interaction after diabetic stroke.

References

Aug 21, 2002·Cerebrovascular Diseases·George Khechinashvili, Kjell Asplund
Mar 10, 2006·Neurology·H AyA G Sorensen
May 10, 2006·Neurology·William P Cheshire, Clifford B Saper
Jun 16, 2007·Stroke; a Journal of Cerebral Circulation·Jane ProsserUNKNOWN VISTA Investigators
Jul 4, 2007·Circulation·Martin A Samuels
Aug 9, 2008·Annals of Neurology·Sohei YoshimuraKazuo Minematsu
Sep 5, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Lihua SunBaofeng Yang
May 28, 2009·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Ling WangBaofeng Yang
Jul 7, 2009·Neuromolecular Medicine·Gokhan Yilmaz, D Neil Granger
Jan 20, 2010·Lancet Neurology·Sandeep KumarLouis R Caplan
Feb 20, 2010·Nature Reviews. Immunology·Jurg Tschopp, Kate Schroder
Aug 28, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Lihua SunBaofeng Yang
Jan 11, 2011·Nature Medicine·Bolormaa VandanmagsarVishwa Deep Dixit
Jul 9, 2011·Nature Medicine·Costantino Iadecola, Josef Anrather
Aug 20, 2011·Stroke; a Journal of Cerebral Circulation·Qian JiaYongjun Wang
Sep 7, 2013·Stroke; a Journal of Cerebral Circulation·Hiroto IshikawaCesar V Borlongan
Feb 6, 2014·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Adviye ErgulSusan C Fagan
May 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wenxiu LiuXinhua Yin
Apr 26, 2016·Translational Stroke Research·Jessica M Cassidy, Steven C Cramer
Jan 20, 2017·Translational Stroke Research·Jieli ChenMichael Chopp
Mar 3, 2017·Annals of Neurology·Thomas KrauseChristian H Nolte
Aug 5, 2017·Circulation Research·Zhili ChenJieli Chen
Oct 13, 2017·The Journal of Experimental Medicine·Hua JiangRongbin Zhou
Oct 13, 2017·Annals of Neurology·Michael BieberChristoph Kleinschnitz
Oct 14, 2017·International Journal of Molecular Sciences·Masato KanazawaTakayoshi Shimohata
Dec 11, 2017·Basic Research in Cardiology·Dongling LiuXianwei Wang
Jul 27, 2018·Journal of Neurotrauma·Qiang ZhaoJieli Chen
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Shubei MaJun Chen
Oct 26, 2018·Stroke; a Journal of Cerebral Circulation·Alexandre MelouxCatherine Vergely
Dec 5, 2018·Lancet Neurology·Jan F ScheitzMatthias Endres
Aug 23, 2019·Stroke; a Journal of Cerebral Circulation·João Pedro MartoAna Catarina Fonseca

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Citations

Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eleonora MezzaromaStefano Toldo

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Methods Mentioned

BETA
PCR
ELISA

Software Mentioned

ImageJ
Prism7
GraphPad7
Vevo 2100

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