PMID: 11606030Oct 19, 2001Paper

Macrophage-oriented cytotoxic activity of novel triterpene saponins extracted from roots of Securidaca inappendiculata

International Immunopharmacology
S YuiM Yamazaki

Abstract

It is recognized that macrophages in peripheral tissues often proliferate under pathological conditions such as tumors, inflammation and atherosclerosis. Because the growth state of macrophages is believed to be a factor regulating the pathological process of the diseases, substances that regulate macrophage growth or survival may be useful for disease control. In this paper, we identified the activity inhibiting macrophage growth in a hot water extract of roots of Securidaca inappendiculata. The extract markedly inhibited macrophage colony-stimulating factor (M-CSF/CSF-1)-induced growth of macrophages, whereas it exerted a less potent effect on growth of Concanavalin A (Con A)-stimulated thymocytes or M-CSF-stimulated bone marrow cells. The inhibition of macrophage growth was caused by a cytotoxic effect rather than a cytostatic effect. Cell death was due to the induction of apoptosis, as judged by staining with terminal deoxynucleotidyl transferase-mediated d-UTP nick end labelling (TUNEL). The cytotoxic activity seemed to be specific to peripheral macrophages; it showed a weak effect on the growth and survival of tumor cell lines including a macrophage-like cell line, J-774.1. Moreover, the saponin fraction induced apoptotic...Continue Reading

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Citations

Dec 1, 2006·Cardiovascular Drugs and Therapy·Qin ZhangQiang Wang
Dec 21, 2002·The British Journal of Nutrition·George FrancisKlaus Becker
Jan 7, 2014·Chemical & Pharmaceutical Bulletin·Minpei KurodaYoshihiro Mimaki
Feb 27, 2007·Journal of Zhejiang University. Science. B·Zahid Iqbal RajputAbdullah G Arijo
Jun 17, 2010·Fitoterapia·Shuli ManChangxiao Liu
Aug 25, 2004·Journal of Ethnopharmacology·S G SpargJ van Staden
Sep 11, 2004·Bioorganic & Medicinal Chemistry·Mohamed HaddadMarie-Aleth Lacaille-Dubois
Jul 4, 2018·Archives of Virology·Wahid H El-DabaeIsmail M Reda
Feb 23, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Pallavi SharmaNitesh Kumar Poddar

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis