Macrophage phagocytic activity toward adhering staphylococci on cationic and patterned hydrogel coatings versus common biomaterials

Acta Biomaterialia
Joana F Da Silva DominguesH J Busscher

Abstract

Biomaterial-associated-infection causes failure of biomaterial implants. Many new biomaterials have been evaluated for their ability to inhibit bacterial colonization and stimulate tissue-cell-integration, but neglect the role of immune cells. This paper compares macrophage phagocytosis of adhering Staphylococcus aureus on cationic-coatings and patterned poly(ethylene)glycol-hydrogels versus common biomaterials and stainless steel in order to identify surface conditions that promote clearance of adhering bacteria. Staphylococci were allowed to adhere and grow on the materials in a parallel-plate-flow-chamber, after which murine macrophages were introduced. From the decrease in the number of adhering staphylococci, phagocytosis-rates were calculated, and total macrophage displacements during an experiment determined. Hydrophilic surfaces had the lowest phagocytosis-rates, while common biomaterials had intermediate phagocytosis-rates. Patterning of poly(ethylene)glycol-hydrogel coatings increased phagocytosis-rates to the level of common biomaterials, while on cationic-coatings phagocytosis-rates remained relatively low. Likely, phagocytosis-rates on cationic coatings are hampered relative to common biomaterials through strong el...Continue Reading

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Citations

May 2, 2016·Biomaterials·Yi WangK Scott Phillips
Oct 25, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Yuliang DongYongyue Wang
Mar 27, 2018·Annual Review of Analytical Chemistry·Yi WangK Scott Phillips
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Dec 6, 2016·Frontiers in Microbiology·Rahul MittalXue Z Liu
Aug 10, 2021·APL Bioengineering·Linan CuiEvelyn K F Yim
Dec 16, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Laijun XuJiyao Li

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