PMID: 9429095Jan 16, 1998Paper

Macrophage phagocytosis of polyethylene particulate in vitro

Journal of Biomedical Materials Research
I VoronovE L Boynton

Abstract

In this study, an in vitro model has been developed to examine the interactions of macrophages with ultrahigh molecular-weight polyethylene (UHMWPE) and high-density polyethylene (HDPE) particles. Polyethylene particles are the major constituent of the material debris formed as a result of orthopedic implant wear. However, the study of polyethylene particle interactions with cells has been limited. UHMWPE (18-20 microns) and HDPE (4-10 microns) were suspended in soluble collagen type I and subsequently solidified on glass coverslips. The particle chemistry was characterized by Fourier transform infra-red spectroscopy (FT-IR) and X-ray photoelectron spectroscopy (XPS). Mouse cell line macrophages (IC-21) were established on the collagen-particle substrata and maintained for up to 24 h. The response of the cells to the particles was examined by light and transmission electron microscopy (LM and TEM), as well as by scanning electron microscopy (SEM), and compared to cells on control collagen surfaces without particles. Histological analysis of the samples revealed that the macrophages surrounded larger particles (18-20 microns) and the cells appeared to be attached to the surface of the particles, and the smaller particles (4-10 m...Continue Reading

References

Mar 24, 1988·The New England Journal of Medicine·R B Johnston
Sep 1, 1995·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·A S ShanbhagT T Glant
Nov 1, 1994·The Journal of Bone and Joint Surgery. American Volume·K J MargeviciusK Merritt
Feb 1, 1994·The Journal of Bone and Joint Surgery. American Volume·K J KimH E Rubash
Jan 1, 1994·Journal of Biomedical Materials Research·A S ShanbhagT T Glant
Sep 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T T GlantJ O Galante
Jun 1, 1993·The Journal of Bone and Joint Surgery. American Volume·S M HorowitzA H Burstein

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Citations

Jan 27, 2011·Seminars in Immunopathology·Isabelle CatelasSandra Utzschneider
Jul 11, 2007·Journal of Materials Science. Materials in Medicine·Y M YangX S Gu
Aug 5, 2003·Biomaterials·Bruce PanilaitisDavid L Kaplan
Jun 1, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Miho IwaseTatsuo Itoh
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Yanming BiEdward M Greenfield
Aug 10, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·David R ChoSteven R Goldring
Jun 6, 2002·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M BergmanM Djaldetti
Feb 19, 2010·Journal of Biomedical Materials Research. Part a·Amanda W BridgesAndrés J García
Dec 12, 2012·Journal of Biomedical Materials Research. Part a·Xidong CuiJack J Jiang
Jul 25, 2006·Journal of Biochemical and Biophysical Methods·Hsu-Wei FangChun-Hsiung Huang
Feb 4, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Dariush FirouziHabiba Bougherara
Aug 22, 2000·Journal of Biomedical Materials Research·E L BoyntonJ P Santerre
Dec 18, 2001·Journal of Biomedical Materials Research·S J CharleboisR A Smith
Dec 2, 2004·Journal of Biomedical Materials Research. Part a·F TavazzaniE L Boynton
May 26, 2005·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Bernd BaumannChristof P Rader
Nov 23, 2005·Biomedizinische Technik. Biomedical Engineering·A WilkeS Endres
Dec 13, 2006·Biomedizinische Technik. Biomedical Engineering·Bernd BaumannChristof P Rader
Jul 13, 2002·Journal of Biomedical Materials Research·S XingE L Boynton
Jul 10, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Bill BraggR Lane Smith
Apr 30, 2008·Journal of Biomedical Materials Research. Part a·Richard ChiuStuart B Goodman
Feb 24, 2001·Journal of Biomedical Materials Research·J A BainbridgeN Al-Saffar
Nov 5, 2003·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hsu-Wei FangJan V Sengers
Jun 21, 2005·Journal of Biomedical Materials Research. Part a·Ryusuke NakaokaToshie Tsuchiya
Jul 25, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·H BaudrillerD Moukoko
May 10, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Michael KovochichBrent L Finley
Dec 22, 1999·Journal of Biomedical Materials Research·A U DanielsR A Smith
Mar 16, 2000·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·E Ingham, J Fisher
May 3, 2005·Clinical Orthopaedics and Related Research·Jennifer WaddellErin L Boynton
Nov 4, 2009·Journal of Diabetes Science and Technology·Amanda W Bridges, Andrés J García

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