Macrophage Polarization as a Therapeutic Target in Myocardial Infarction

Current Drug Targets
Yuanyuan Cheng, Jianhui Rong

Abstract

Myocardial infarction is characterized by the interruption of blood flow through the heart, directly causing mortality and disability worldwide. Cardiac macrophages exhibit distinct phenotypes (e.g., M1 or M2) and functions (e.g., proinflammatory or anti-inflammatory) in response to the alterations of myocardial microenvironment, and subsequently exacerbate or resolve inflammation in the infarcted hearts. Regulation of macrophage polarization was implicated in myocardial infarction for the quality and outcome of cardiac healing. The purpose of this review was to summarise the current understanding on the regulation of macrophage polarization in myocardial infarction and highlight the therapeutic potential of pharmacological regulators in the treatment of myocardial injury via modulating macrophage polarization. Timely control of M2/M1 ratio by endogenous mediators and pharmacological regulators should help the resolution of inflammation, promote wound healing and prevent cardiac fibrosis after myocardial infarction. Macrophage polarization deserves better investigations as the therapeutic target for the development of novel drugs against myocardial injury.

Citations

Mar 29, 2019·Expert Opinion on Therapeutic Targets·Yuanyuan Cheng, Jianhui Rong
Jan 31, 2020·Canadian Journal of Physiology and Pharmacology·Xiaojie JiangHong Gao
Dec 14, 2018·Basic Research in Cardiology·Mira JungThomas Thum
Jun 18, 2020·Research and Practice in Thrombosis and Haemostasis·Breanne H Y GibsonJonathan G Schoenecker
Mar 29, 2019·Experimental Dermatology·Ferhan MuneebRalf Paus
Jan 12, 2021·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·Andrés A HerradaMatthias Piesche
Oct 7, 2020·Pharmacology & Therapeutics·Qirong LuMaría-Aránzazu Martínez
Mar 7, 2021·Nature Communications·Icia Santos-ZasHafid Ait-Oufella
Jun 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Luciana P TavaresLirlândia P Sousa
Apr 4, 2021·International Journal of Molecular Sciences·Yevgeniy KimArman Saparov
Oct 1, 2021·Current Pharmaceutical Design·Bing SunYu Mao

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