Macrophage production of inflammatory mediators is potently inhibited by a butyric acid derivative demonstrated to inactivate antigen-stimulated T cells

International Immunopharmacology
Lee S F SoderbergKathleen M Gilbert

Abstract

The butyric acid derivative, 2-(4-morpholynl) ethyl butyrate hydrochloride (MEB), has been reported to induce antigen-specific T cell unresponsiveness and to block T cell-mediated graft-versus-host disease. As a potential therapeutic agent, it was important to determine the effects of MEB on other cells that contribute to immunopathology. Accordingly, we tested the effects of MEB on macrophage functions. MEB did not affect macrophage viability, phagocytic activity, or the activation-induced up-regulation of molecules associated with antigen presentation: MHC-II, CD86, CD40, or ICAM-1. However, MEB potently inhibited activation-induced production of inflammatory mediators, including tumor necrosis factor-alpha (TNF-alpha), IL-6, chemokine CCL2 and nitric oxide (NO). MEB inhibited the induction of NO synthase (NOS2), which is necessary for inducible NO, and inhibited nuclear translocation of NFkappaB, suggesting that MEB interferes with the signaling pathway involved in NOS2 induction. Thus, while inducing specific T cell unresponsiveness, MEB also exerts anti-inflammatory activity by acting on macrophages to suppress production of cytokines and NO.

Citations

Apr 21, 2009·International Journal of Food Microbiology·Uma BabuRichard B Raybourne
May 27, 2006·Veterinary Immunology and Immunopathology·Thomas E Weber, Brian J Kerr
Sep 19, 2006·International Immunopharmacology·R Erik EdensKathleen M Gilbert
Aug 12, 2009·International Immunopharmacology·A Selma DagtasKathleen M Gilbert
May 2, 2019·The Journal of Clinical Investigation·David N Fredricks

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