Macrophage regulation of graft-vs -host disease

World Journal of Clinical Cases
Ya-Qun HongXiao-Fan Li

Abstract

Hematopoietic stem cell transplantation has become a curative choice of many hematopoietic malignancy, but graft-vs-host disease (GVHD) has limited the survival quality and overall survival of hematopoietic stem cell transplantation. Understanding of the immune cells' reaction in pathophysiology of GVHD has improved, but a review on the role of macrophages in GVHD is still absent. Studies have observed that macrophage infiltration is associated with GVHD occurrence and development. In this review, we summarize and analyze the role of macrophages in GVHD based on pathophysiology of acute and chronic GVHD, focusing on the macrophage recruitment and infiltration, macrophage polarization, macrophage secretion, and especially interaction of macrophages with other immune cells. We could conclude that macrophage recruitment and infiltration contribute to both acute and chronic GVHD. Based on distinguishing pathology of acute and chronic GVHD, macrophages tend to show a higher M1/M2 ratio in acute GVHD and a lower M1/M2 ratio in chronic GVHD. However, the influence of dominant cytokines in GVHD is controversial and inconsistent with macrophage polarization. In addition, interaction of macrophages with alloreactive T cells plays an impo...Continue Reading

References

Dec 13, 2005·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra H FilipovichMary E D Flowers
Jun 23, 2006·The New England Journal of Medicine·Silvia Svegliati BaroniArmando Gabrielli
Apr 18, 2007·Nature Reviews. Immunology·Warren D Shlomchik
Nov 26, 2008·Nature Reviews. Immunology·David M Mosser, Justin P Edwards
Mar 14, 2009·Lancet·James L M FerraraErnst Holler
Jan 27, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marina G M CastorVanessa Pinho
Sep 22, 2010·Nature Immunology·Subhra K Biswas, Alberto Mantovani
May 12, 2011·Disease Models & Mechanisms·Mark A Schroeder, John F DiPersio
Mar 2, 2012·The Journal of Clinical Investigation·Antonio Sica, Alberto Mantovani
Apr 27, 2013·Nature·Thomas A WynnJeffrey W Pollard
Jun 25, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stefanie HaaskenBryce A Binstadt
Jul 10, 2013·Transplantation·Junko Tashiro-YamajiRyotaro Yoshida
Jul 19, 2013·ISRN Dermatology·G E PiérardC Piérard-Franchimont
Jun 11, 2014·Blood·Shernan G HoltanDaniel J Weisdorf
Jun 11, 2014·Blood·Boglarka Gyurkocza, Brenda M Sandmaier
Jun 25, 2014·Nature Reviews. Clinical Oncology·Sung Won Choi, Pavan Reddy
Aug 17, 2014·Journal of Molecular and Cellular Cardiology·Pooja ShivshankarClaude Jourdan Le Saux
Aug 27, 2014·The Journal of Clinical Investigation·Kylie A AlexanderKelli P A MacDonald
Dec 23, 2014·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Madan H JagasiaMary E D Flowers
Feb 4, 2015·Blood·Stefanie Sarantopoulos, Jerome Ritz
Feb 7, 2015·Investigative Ophthalmology & Visual Science·Samantha HerretesVictor L Perez
Feb 11, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Bixia PanDongwen Zheng

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
transgenic

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Makoto HirokawaKen-ichi Sawada
Ryōikibetsu shōkōgun shirīzu
H Kodo, S Asano
Bone Marrow Transplantation
A L Gilman, Kirk R Schultz
Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete
R TravnikS Karrer
© 2022 Meta ULC. All rights reserved