Macrophage response during axonal regeneration in the axolotl central and peripheral nervous system

Neuroscience
P S ZammitD Tonge

Abstract

We have used a monoclonal antibody (5F4) and Griffonia lectin to study the recruitment of macrophages after crushing axolotl central and peripheral axons. In both cases axonal regeneration begins within one to two days and, in the CNS, proceeds at a rate of about 0.05 mm per day. However, in the spinal cord, macrophage entry is restricted to the lesion site whilst in peripheral nerves macrophages rapidly enter the distal nerve stump after injury. These results suggest that the role (if any) played by macrophages during axonal regeneration may differ in these two situations.

References

Apr 29, 1977·Cell and Tissue Research·L J Stensaas, E R Feringa
Feb 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·C M O'HaraE A Chernoff
Jan 22, 1991·The Journal of Comparative Neurology·N HolderD A Tonge
Feb 22, 1986·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·J D ClarkeN H Holder
Jun 17, 1988·Neuroscience Letters·J D ClarkeN Holder
Feb 1, 1987·The Journal of Clinical Investigation·C F Nathan
Apr 1, 1987·Journal of Neurocytology·W J Streit, G W Kreutzberg
Jan 1, 1969·The Journal of Comparative Neurology·C Schonbach
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·D E MaddoxI J Goldstein
Jan 1, 1989·The European Journal of Neuroscience·E R LunnS Gordon
Jan 1, 1990·Tissue & Cell·E A ChernoffM W Egar

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Citations

Jan 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Fang ZhangJonathan D W Clarke
Oct 25, 2016·Acta histochemica·Turan Demircanİlknur Keskin
May 16, 2000·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·A L MescherJ J Brokaw
Jul 15, 2003·The International Journal of Neuroscience·Levent Sarikcioglu, Olcay Ozkan
Jun 24, 2017·Journal of Leukocyte Biology·Syed F Hassnain WaqasTamás Röszer
Nov 19, 2019·Frontiers in Immunology·Nathaniel EnosEllen A G Chernoff

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