Macrophage response to chitosan/poly-(γ-glutamic acid) nanoparticles carrying an anti-inflammatory drug

Journal of Materials Science. Materials in Medicine
Raquel Madeira GonçalvesMário Adolfo Barbosa

Abstract

The inflammatory response to biomaterials, traditionally viewed as detrimental, is nowadays considered essential for tissue repair/regeneration, being macrophages recognized as the key players in resolving inflammation. Here, the preparation of chitosan (Ch)/poly-(γ-glutamic acid) (γ-PGA) nanoparticles (NPs) as vehicle for a non-steroid anti-inflammatory drug, diclofenac (Df), is described and the response of primary human macrophages to this system is evaluated. Df was incorporated in Ch/γ-PGA NPs at controlled pH (5.0) (maximum 0.05 mg/ml). The components molar ratio and order of addition revealed to be critical to obtain NPs (315 ± 50 nm with 0.36 ± 0.06 polydispersion index). Df was released at physiological pH and this drug-delivery system was proved to be non toxic to macrophages, being rapidly internalized (95 %). Importantly, efficacy of Df-NPs was confirmed by their ability of inhibit/revert PGE2 production of activated macrophages. Therefore, Df-NPs could contribute to stifle local inflammatory reactions, namely those associated with biomaterials.

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Citations

Nov 14, 2015·Tissue Engineering. Part C, Methods·Graciosa Q TeixeiraCornelia Neidlinger-Wilke
Apr 30, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nadia RuoccoMaria Costantini
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Mar 7, 2020·International Journal of Molecular Sciences·Carla CunhaRaquel M Goncalves
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Mar 2, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Zhuqing Li, Kaitlin M Bratlie
Mar 7, 2021·Gels·Xabier MoralesCarlos Ortiz-de-Solorzano

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