PMID: 7544909Sep 1, 1995Paper

Macrophage response to microbial pathogens: modulation of the expression of adhesion, CD14, and MHC class II molecules by viruses, bacteria, protozoa and fungi

Scandinavian Journal of Immunology
R KellerP Joller

Abstract

The ability of inactivated viruses, bacteria, protozoa and fungi to modulate the expression of CD14, CD49d, CD49f, CD11a (LFA-1), and CD54 (ICAM-1) molecules in unprimed bone marrow-derived mononuclear phagocytes (BMM phi) was investigated by means of flow cytometry. Incubation with bacterial agents resulted in the large majority of experimental situations in enhanced expression of these macrophage surface molecules. In contrast, viruses and fungi down-regulated the expression of several adhesion receptors, especially integrins. Amplification of MHC class II expression triggered in macrophages by interferon gamma was clearly inhibited by viruses, bacteria, protozoa and fungi. The findings explain earlier results showing that, under the same experimental conditions, bacterial agents are, for the most part, potent stimulators of secretory and cell-mediated macrophage activities while viruses, protozoa and fungi are poor in this respect.

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Citations

Mar 6, 1999·Current Opinion in Microbiology·R H Valdivia, S Falkow
Feb 8, 2006·The Journal of Allergy and Clinical Immunology·Leena von Hertzen, Tari Haahtela
Sep 18, 2002·Scandinavian Journal of Immunology·A I MedeirosL H Faccioli
Jan 5, 1999·Clinical and Diagnostic Laboratory Immunology·J JasonW R Jarvis

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